Møller Peter, Folkmann Janne Kjaersgaard, Forchhammer Lykke, Bräuner Elvira Vaclavik, Danielsen Pernille Høgh, Risom Lotte, Loft Steffen
Institute of Public Health, Department of Occupational and Environmental Health, University of Copenhagen, Oster Farimagsgade 5, Build 5, 2nd Floor, P.O. 2099, DK-1014 Copenhagen K, Denmark.
Cancer Lett. 2008 Jul 18;266(1):84-97. doi: 10.1016/j.canlet.2008.02.030. Epub 2008 Mar 25.
There is growing concern that air pollution exposure increases the risk of lung cancer. The mechanism of action is related to particle-induced oxidative stress and oxidation of DNA. Humans exposed to urban air with vehicle emissions have elevated levels of oxidized guanine bases in blood cells and urine. Animal experimental studies show that pulmonary and gastrointestinal exposure is associated with elevated levels of oxidized guanines in the lung and other organs. Collectively, there is evidence indicating that exposure to traffic-related air pollution particles is associated with oxidative damage to DNA and this might be associated with increased risk of cancer.
人们越来越担心暴露于空气污染会增加患肺癌的风险。其作用机制与颗粒物诱导的氧化应激和DNA氧化有关。暴露于含有车辆排放物的城市空气中的人，其血细胞和尿液中的氧化鸟嘌呤碱基水平会升高。动物实验研究表明，肺部和胃肠道暴露与肺部及其他器官中氧化鸟嘌呤水平升高有关。总体而言，有证据表明，暴露于与交通相关的空气污染颗粒物与DNA的氧化损伤有关，这可能与癌症风险增加有关。
