Perale G, Giordano C, Daniele F, Tunesi M, Colombo P, Gottardo L, Maccagnan S, Masi M
Department of Chemistry, Material Science and Chemical Engineering, Politecnico di Milano, Milan, Italy.
Int J Artif Organs. 2008 Mar;31(3):272-8. doi: 10.1177/039139880803100312.
A new process, based on the micro-co-extrusion of preceramic precursors, has been studied for manufacturing ceramic microelectrodes to be used in biomedical applications. Commercially available silicon polymers were applied and proper doping resulted in electrically conductive ceramic filaments. Chemical reticulation and high-temperature pyrolysis were applied to convert the polymeric resins into Si-O-C ceramic materials. Circular microelectrodes were manufactured with diameters between 100 microm and 5 mm with a different number of inner conductive lines (from 1 to 80). The flexural strength of the filaments depended on the outer diameter size; doping with carbon black produced filaments with an average conductivity of approximately 0.4 S/cm for a 50% weight carbon black load. The results achieved by in vitro studies confirmed a good biological performance of Si-O-C ceramic structures with both hard and soft tissue cell models.
一种基于陶瓷前驱体微共挤出的新工艺已被研究用于制造生物医学应用中的陶瓷微电极。应用了市售的硅聚合物，适当的掺杂产生了导电陶瓷细丝。通过化学网状化和高温热解将聚合树脂转化为Si-O-C陶瓷材料。制造出了直径在100微米至5毫米之间、具有不同数量内导线（从1到80）的圆形微电极。细丝的抗弯强度取决于外径尺寸；对于50%重量的炭黑负载，用炭黑掺杂产生的细丝平均电导率约为0.4 S/cm。体外研究取得的结果证实了Si-O-C陶瓷结构在硬组织和软组织细胞模型中均具有良好的生物学性能。
