Pepine Carl J, Nichols Wilmer W
Division of Cardiovascular Medicine, Gainesville, FL 32610-0277, USA.
Clin Cardiol. 2007 Feb;30(2 Suppl 1):I4-9. doi: 10.1002/clc.20048.
With our success in management of acute coronary syndromes (ACS), aging population and epidemics of diabetes and obesity, the management of patients with chronic coronary artery disease is becoming an increasing important part of clinical practice. Although the rates of death and myocardial infarction (MI) in this group of patients are not high as a group, a subgroup has very high risk but many have poor quality of life related to limiting angina. The purpose of this article is to review the pathophysiology of the chronic angina syndrome to provide an improved understanding of the basis for the comprehensive management required to yield patient benefits. Where possible, targets for novel therapeutic approaches are highlighted.
随着我们在急性冠状动脉综合征（ACS）管理方面取得成功，人口老龄化以及糖尿病和肥胖症的流行，慢性冠状动脉疾病患者的管理正日益成为临床实践的重要组成部分。尽管这类患者作为一个整体的死亡率和心肌梗死（MI）发生率并不高，但有一个亚组风险极高，而且许多患者因心绞痛受限而生活质量较差。本文旨在综述慢性心绞痛综合征的病理生理学，以便更好地理解为使患者获益所需的综合管理基础。在可能的情况下，突出新型治疗方法的靶点。
