Savino Francesco, Liguori Stefania Alfonsina, Fissore Maria Francesca, Palumeri Elisabetta, Calabrese Roberto, Oggero Roberto, Silvestro Leandra, Miniero Roberto
Department of Pediatrics, Regina Margherita Children's Hospital, University of Turin, Italy.
J Pediatr Gastroenterol Nutr. 2008 Mar;46(3):348-51. doi: 10.1097/MPG.0b013e318159e6bf.
We carried out a cross-sectional study of 115 healthy infants, younger than 6 months old, exclusively breast-fed or formula-fed, to investigate correlations between circulating leptin concentrations and body composition measurements. Serum leptin was evaluated with radioimmunoassay, and body composition with bioelectrical impedance analysis. Multiple regression analysis showed a relationship between serum leptin and body mass index in the entire study population (P = 0.042). There was a significant negative relationship between serum leptin and phase angle (P = 0.006) in formula-fed infants. Serum leptin was positively related to subscapular skinfold thickness (P = 0.055) and negatively to reactance (P = 0.057) only in formula-fed infants, although the differences were just below significance. Serum leptin concentration was higher in breast-fed infants (P = 0.002), and was not correlated with body composition parameters. This study indicates that there is a relation between leptin and infant body composition in the first months of life, although the link needs to be explored further.
我们对115名6个月以下、纯母乳喂养或配方奶喂养的健康婴儿进行了一项横断面研究，以调查循环瘦素浓度与身体成分测量值之间的相关性。采用放射免疫分析法评估血清瘦素，采用生物电阻抗分析法评估身体成分。多元回归分析显示，在整个研究人群中，血清瘦素与体重指数之间存在关联（P = 0.042）。在配方奶喂养的婴儿中，血清瘦素与相角之间存在显著负相关（P = 0.006）。仅在配方奶喂养的婴儿中，血清瘦素与肩胛下皮褶厚度呈正相关（P = 0.055），与电抗呈负相关（P = 0.057），尽管差异略低于显著性水平。母乳喂养婴儿的血清瘦素浓度较高（P = 0.002），且与身体成分参数无关。这项研究表明，在生命的最初几个月里，瘦素与婴儿身体成分之间存在关联，尽管这种联系还需要进一步探索。
