de Pedro-Cuesta J
Department of Neurology, Huddinge Hospital, Sweden.
Acta Neurol Scand. 1991 Oct;84(4):357-65. doi: 10.1111/j.1600-0404.1991.tb04969.x.
Parkinson's disease (PD) surveys and death-record studies in European populations were reviewed. Particular attention was given to methodological aspects. Two sets of quality criteria were used. Four door-to-door surveys revealed underdiagnosis of prevalent idiopathic parkinsonism ranging from 30% to 71%. Quality surveys based on medical records were scarce. The analysis of a) the time relationships between the diagnostic process and the study period for measurements, and b) a variation observed in the shape of the curve for age-specific prevalences, suggested that both incidence and prevalence were underestimated by these surveys, especially among the elderly. In the UK, Denmark and Sweden, mortality from parkinsonism increased over time for ages over 70 years, but decreased for the younger age groups. A two-fold variation in mortality was found between countries. It is concluded that PD is widely distributed in Europe, and that most geographical differences in reported disease occurrence can be explained by methodological variations in measurements. The pattern of variation of age-specific figures was similar for mortality and prevalence. This might reflect decreasing prevalences among those aged under 70 years and increasing ascertainment in the elderly. There is a need for research methods for specific purposes in this field to be developed.
对欧洲人群中帕金森病（PD）的调查和死亡记录研究进行了综述。特别关注了方法学方面。使用了两组质量标准。四项挨家挨户的调查显示，原发性帕金森病的漏诊率在30%至71%之间。基于医疗记录的高质量调查很少。对a）诊断过程与测量研究期间的时间关系，以及b）特定年龄患病率曲线形状中观察到的变化进行分析后表明，这些调查低估了发病率和患病率，尤其是在老年人中。在英国、丹麦和瑞典，70岁以上人群帕金森病的死亡率随时间增加，但年轻年龄组的死亡率下降。各国之间发现死亡率存在两倍的差异。得出的结论是，PD在欧洲广泛分布，报告的疾病发生率的大多数地理差异可以通过测量方法的差异来解释。特定年龄数据的变化模式在死亡率和患病率方面相似。这可能反映了70岁以下人群患病率的下降以及老年人确诊率的上升。需要开发该领域针对特定目的的研究方法。
