Ferreras Antonio, Pablo Luís E, Garway-Heath David F, Fogagnolo Paolo, García-Feijoo Julián
Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain.
Invest Ophthalmol Vis Sci. 2008 Jul;49(7):3018-25. doi: 10.1167/iovs.08-1775. Epub 2008 Mar 31.
To establish a map relating visual field (VF) test points to corresponding areas of the retinal nerve fiber layer (RNFL) measured with optical coherence tomography (OCT) in patients with glaucomatous optic neuropathy.
One hundred four consecutive subjects with open-angle glaucoma were prospectively selected. All subjects underwent standard automated perimetry (SAP) and imaging with OCT. Factor analyses of the mean thresholds for the SAP test points were performed, independently for each hemifield, to define regions of related points. Pearson correlations were then calculated between the VF regions and peripapillary RNFL thickness measured with OCT at each of the 12 clock-hour positions. A map relating the VF regions to the OCT sectors was plotted based on the strongest correlations between both techniques.
Factor analysis distributed the VF points into five VF regions for each hemifield. A slightly asymmetric distribution of VF regions was obtained for the upper and lower points, with respect to the horizontal meridian. Mild to moderate correlations were observed between the VF regions and RNFL thickness. The superior VF regions and RNFL segments correlated most strongly at the 6- and 7-o'clock positions (r = 0.4-0.5).
There was a moderate association between the VF regions and the RNFL thickness in patients with glaucomatous optic neuropathy, as measured by OCT. Within sectors of the RNFL, there was some overlap in the representation of the VF regions. The map obtained validates previously reported clinical findings and contributes to a better understanding of the relationship between structure and function in patients with glaucoma.
建立一张地图，将青光眼性视神经病变患者视野（VF）测试点与通过光学相干断层扫描（OCT）测量的视网膜神经纤维层（RNFL）相应区域关联起来。
前瞻性选取104例连续的开角型青光眼患者。所有受试者均接受标准自动视野计检查（SAP）和OCT成像。对SAP测试点的平均阈值进行因子分析，每个半视野独立进行，以定义相关点的区域。然后计算VF区域与在12个钟点位置处通过OCT测量的视乳头周围RNFL厚度之间的Pearson相关性。基于两种技术之间的最强相关性，绘制一张将VF区域与OCT扇区关联起来的地图。
因子分析将每个半视野的VF点分为五个VF区域。相对于水平子午线，上下点的VF区域分布略有不对称。在VF区域和RNFL厚度之间观察到轻度至中度的相关性。上VF区域和RNFL节段在6点和7点位置相关性最强（r = 0.4 - 0.5）。
通过OCT测量，青光眼性视神经病变患者的VF区域与RNFL厚度之间存在中度关联。在RNFL的各扇区内，VF区域的表现存在一些重叠。所获得的地图验证了先前报道的临床发现，并有助于更好地理解青光眼患者结构与功能之间的关系。
