Abad S, Monnet D, Caillat-Zucman S, Mrejen S, Blanche P, Chalumeau M, Mouthon L, Dhote R, Brézin A P
Service de Médecine Interne, Laboratoire de recherche clinique et thérapeutique UPRES EA3409, Université Paris XIII, Faculté Léonard de Vinci, Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris, Paris, France.
Ocul Immunol Inflamm. 2008 Jan-Feb;16(1):3-8. doi: 10.1080/09273940801923895.
To assess in patients followed in a French referral center the clinical spectrum of Vogt-Koyanagi-Harada (VKH) disease and the HLA-DRB1*04 genotype.
Patients previously diagnosed as having VKH disease were re-evaluated in a cross-sectional study using the VKH Committee's revised criteria. High-resolution HLA-DRB1 genotyping was performed.
Eleven white patients satisfied ophthalmologic diagnostic criteria. All originated from Mediterranean countries. Nine and 3 patients had neurologic and/or cutaneous abnormalities, respectively. Among DRB104-positive patients, the HLA-DRB10405 subtype was 71%.
These VKH patients predominantly had an incomplete form. The HLA-DRB1*0405 subtype allele was enriched in a group of Mediterranean stock.
