Marel Anna-Kristina, Lizard Gérard, Izard Jean-Claude, Latruffe Norbert, Delmas Dominique
INSERM U866, Dijon, France.
Mol Nutr Food Res. 2008 May;52(5):538-48. doi: 10.1002/mnfr.200700185.
Resveratrol may function as a cancer chemopreventive agent. However, few data are available on the antitumoral activities of its dimer, epsilon-viniferin, also present in human diet. So, the effects of resveratrol, epsilon-viniferin, of their acetylated forms (resveratrol triacetate, epsilon-viniferin pentaacetate) and of vineatrol (a wine grape extract) were compared on human adenocarcinoma colon cells. Resveratrol and resveratrol triacetate inhibit cell proliferation and arrest cell cycle. epsilon-Viniferin and epsilon-viniferin pentaacetate slightly reduce cell proliferation. Vineatrol inhibits cell proliferation and favors an accumulation in the S phase of the cell cycle. Consequently, resveratrol triacetate and vineatrol could constitute new putative anticancer agents on colon carcinoma.
白藜芦醇可能作为一种癌症化学预防剂发挥作用。然而，关于其同样存在于人类饮食中的二聚体ε-葡萄素的抗肿瘤活性，可用数据很少。因此，比较了白藜芦醇、ε-葡萄素、它们的乙酰化形式（白藜芦醇三乙酸酯、ε-葡萄素五乙酸酯）以及葡萄藤提取物对人结肠腺癌细胞的影响。白藜芦醇和白藜芦醇三乙酸酯抑制细胞增殖并使细胞周期停滞。ε-葡萄素和ε-葡萄素五乙酸酯略微降低细胞增殖。葡萄藤提取物抑制细胞增殖并有利于细胞周期S期的积累。因此，白藜芦醇三乙酸酯和葡萄藤提取物可能构成结肠癌新的潜在抗癌剂。
