Benedetti Francesca, Sorrenti Vincenzo, Buriani Alessandro, Fortinguerra Stefano, Scapagnini Giovanni, Zella Davide
Institute of Human Virology, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.
Viruses. 2020 Dec 17;12(12):1458. doi: 10.3390/v12121458.
Balanced nutrition and appropriate dietary interventions are fundamental in the prevention and management of viral infections. Additionally, accurate modulation of the inflammatory response is necessary to achieve an adequate antiviral immune response. Many studies, both in vitro with mammalian cells and in vivo with small animal models, have highlighted the antiviral properties of resveratrol, rapamycin and metformin. The current review outlines the mechanisms of action of these three important compounds on the cellular pathways involved with viral replication and the mechanisms of virus-related diseases, as well as the current status of their clinical use.
均衡营养和适当的饮食干预在病毒感染的预防和管理中至关重要。此外，准确调节炎症反应对于实现充分的抗病毒免疫反应是必要的。许多研究，包括在体外对哺乳动物细胞以及在体内对小动物模型进行的研究，都突出了白藜芦醇、雷帕霉素和二甲双胍的抗病毒特性。本综述概述了这三种重要化合物对与病毒复制相关的细胞途径及病毒相关疾病机制的作用机制，以及它们的临床应用现状。
