Wang Yan-Rang, Zhang Ming, Wang Qian, Yang De-Yi, Li Chao-Lin, Liu Jing, Li Jian-Guo, Li Hao, Yang Xue-Ying
Tianjin Centers for Disease Control and Prevention, 76 Hualong Road, Tianjin 300011, PR China.
Sci Total Environ. 2008 Jun 15;396(1):34-41. doi: 10.1016/j.scitotenv.2008.02.060. Epub 2008 Apr 2.
1,1,1-trichloro-2,2'-bis(4-chlorophenyl)ethane (DDT) exhibits its long persistence in the environment, unusual bioaccumulation, effects on wildlife, and the possibility of long-term adverse effects on human health, especially reproductive toxicity. Despite the prohibition of most persistent organochlorine pesticides in China, the presence of organochlorine residue, including DDT, has been widely indicated in environmental substance. However, scarce information is available about accumulative levels of DDT in human tissues in China. To evaluate levels of DDT and its potential effects on women and children's health in a Chinese pesticide-exposed area, we recruited 50 pairs of mother-child and 50 postpartum women, and determined the levels of total DDT and its four main metabolites (p,p'-DDE, p,p'-DDT, p,p'-DDD, o,p'-DDT) in venous blood, breast milk and umbilical blood cord by gas chromatography. Accordingly, data on reproductive outcomes of mothers and postpartum women and healthy status of children and infants were gathered through a questionnaire and medical examinations. Furthermore, we also assayed the DDT levels of some environmental samples (soil, food, milk, et al.). The levels of DDT in children's blood were higher than that in the women's. As compared to breast milk, the umbilical blood cord and the ventral fat individually demonstrated a significantly lower and higher level of DDT in the postpartum women. DDT was lower in milk and crucian carp than in the soil near the chemical plant. p,p'-DDT and p,p'-DDE were the main metabolites of DDT. Our findings suggested the cumulative effect of DDT in human body in Tianjin, China.
1,1,1-三氯-2,2'-双（4-氯苯基）乙烷（滴滴涕）在环境中具有持久性、异常的生物累积性、对野生动物的影响以及对人类健康产生长期不良影响的可能性，尤其是生殖毒性。尽管中国已禁止使用大多数持久性有机氯农药，但环境物质中广泛检测到包括滴滴涕在内的有机氯残留。然而，关于中国人体组织中滴滴涕累积水平的信息却很少。为了评估中国一个农药暴露地区滴滴涕的水平及其对妇女和儿童健康的潜在影响，我们招募了50对母婴和50名产后妇女，通过气相色谱法测定了静脉血、母乳和脐带血中总滴滴涕及其四种主要代谢物（p,p'-滴滴伊、p,p'-滴滴涕、p,p'-滴滴滴、o,p'-滴滴涕）的水平。相应地，通过问卷调查和医学检查收集了母亲和产后妇女的生殖结局以及儿童和婴儿健康状况的数据。此外，我们还检测了一些环境样本（土壤、食物、牛奶等）中的滴滴涕水平。儿童血液中滴滴涕的水平高于妇女。与母乳相比，产后妇女脐带血和腹部脂肪中滴滴涕的水平分别显著较低和较高。牛奶和鲫鱼中的滴滴涕含量低于化工厂附近土壤中的含量。p,p'-滴滴涕和p,p'-滴滴伊是滴滴涕的主要代谢物。我们的研究结果表明了滴滴涕在中国天津人体中的累积效应。
