Malmeström Clas, Lycke Jan, Haghighi Sara, Andersen Oluf, Carlsson Lena, Wadenvik Hans, Olsson Bob
Sahlgrenska Academy, Department of Neurology, Sahlgrenska University Hospital, Göteborg University, Göteborg, Sweden.
J Neuroimmunol. 2008 May 30;196(1-2):159-65. doi: 10.1016/j.jneuroim.2008.03.001. Epub 2008 Apr 8.
MS is thought to be mediated by CD4(+) T-helper cells. To investigate the importance of CD8(+) cytotoxic T-cells in MS we analyzed peripheral blood T-cells by DNA microarray, and plasma and CSF levels of granzymes from MS patients and controls. Cytotoxic gene expression was decreased in peripheral T-cells from RRMS patients whereas plasma levels of granzymes were unchanged. However, granzyme levels were elevated in the CSF of RRMS patients at relapse compared with controls and remission. Thus, CD8+ T-cell-mediated cytotoxicity is confined to the CSF/CNS compartment in RRMS patients and may be involved in the immunopathogenesis of clinical relapses.
多发性硬化症（MS）被认为是由CD4(+)辅助性T细胞介导的。为了研究CD8(+)细胞毒性T细胞在MS中的重要性，我们通过DNA微阵列分析了外周血T细胞，以及MS患者和对照组血浆及脑脊液中颗粒酶的水平。复发缓解型多发性硬化症（RRMS）患者外周T细胞中的细胞毒性基因表达降低，而血浆中颗粒酶水平未发生变化。然而，与对照组及缓解期相比，RRMS患者复发时脑脊液中的颗粒酶水平升高。因此，RRMS患者中CD8+ T细胞介导的细胞毒性作用局限于脑脊液/中枢神经系统（CSF/CNS）区域，可能参与了临床复发的免疫发病机制。
