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欧盟对食用动物源沙门氏菌和弯曲杆菌分离株的抗菌药物耐药性进行统一监测。

Harmonised monitoring of antimicrobial resistance in Salmonella and Campylobacter isolates from food animals in the European Union.

出版信息

Clin Microbiol Infect. 2008 Jun;14(6):522-33. doi: 10.1111/j.1469-0691.2008.02000.x. Epub 2008 Apr 5.

Abstract

Many Member States of the European Union (EU) currently monitor antimicrobial resistance in zoonotic agents, including Salmonella and Campylobacter. According to Directive 2003/99/EC, Member States shall ensure that the monitoring provides comparable data on the occurrence of antimicrobial resistance. The European Commission asked the European Food Safety Authority to prepare detailed specifications for harmonised schemes for monitoring antimicrobial resistance. The objective of these specifications is to lay down provisions for a monitoring and reporting scheme for Salmonella in fowl (Gallus gallus), turkeys and pigs, and for Campylobacter jejuni and Campylobacter coli in broiler chickens. The current specifications are considered to be a first step towards a gradual implementation of comprehensive antimicrobial resistance monitoring at the EU level. These specifications propose to test a common set of antimicrobial agents against available cut-off values and a specified concentration range to determine the susceptibility of Salmonella and Campylobacter. Using isolates collected through programmes in which the sampling frame covers all epidemiological units of the national production, the target number of Salmonella isolates to be included in the antimicrobial resistance monitoring per Member State per year is 170 for each study population (i.e., laying hens, broilers, turkeys and slaughter pigs). The target number of Campylobacter isolates to be included in the antimicrobial resistance monitoring per Member State per year is 170 for each study population (i.e., broilers). The results of the antimicrobial resistance monitoring are assessed and reported in the yearly national report on trends and sources of zoonoses, zoonotic agents and antimicrobial resistance.

摘要

欧盟的许多成员国目前都在监测包括沙门氏菌和弯曲杆菌在内的人畜共患病原体的抗菌药物耐药性。根据2003/99/EC号指令,成员国应确保监测能提供有关抗菌药物耐药性发生情况的可比数据。欧盟委员会要求欧洲食品安全局制定统一的抗菌药物耐药性监测方案详细规范。这些规范的目标是为家禽(家鸡)、火鸡和猪中沙门氏菌以及肉鸡中空肠弯曲菌和结肠弯曲菌的监测和报告方案制定规定。当前的规范被视为朝着在欧盟层面逐步实施全面抗菌药物耐药性监测迈出的第一步。这些规范提议针对可用的临界值和特定浓度范围测试一组通用的抗菌药物,以确定沙门氏菌和弯曲杆菌的敏感性。利用通过采样框架涵盖国家生产所有流行病学单位的项目收集的分离株,每个成员国每年纳入抗菌药物耐药性监测的沙门氏菌分离株目标数量为每个研究群体(即产蛋鸡、肉鸡、火鸡和屠宰猪)170株。每个成员国每年纳入抗菌药物耐药性监测的弯曲杆菌分离株目标数量为每个研究群体(即肉鸡)170株。抗菌药物耐药性监测结果在关于人畜共患病、人畜共患病原体和抗菌药物耐药性趋势及来源的年度国家报告中进行评估和报告。

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