Machado de Sousa Suzana Orsini, Linhares Ferrazzo Kivia, Mota Loyola Adriano, Dos Santos Jean Nunes, de Araújo Vera Cavalcanti
Department of Oral Pathology, University of São Paulo, São Paulo, Brazil.
Int J Surg Pathol. 2008 Apr;16(2):143-9. doi: 10.1177/1066896907309735. Epub 2008 Apr 7.
In the present study, the immunoprofile of chronic sclerosing sialadenitis, also known as Kuttner tumor, was analyzed. Two cases that occurred in the submandibular gland of male patients were submitted to immunohistochemical reactions to different antibodies. Histological examinations showed a submandibular gland exhibiting various degrees of atrophy with destruction of acini, infiltration by inflammatory cells, and periductal fibrosis. Reactions to cytokeratins (CKs) showed acini and duct remnants positive to CKs 7, 8, 19, and 13. CK14 stained myoepithelial cells around preserved acini and intercalated duct, and also basal cell of excretory ducts, but was negative in proliferating and branching ducts. Smooth muscle actin (SMA) was expressed by myofibroblasts in periductal fibrosis, and an intense expression of extracellular components was also seen. Lymphocyte markers showed, besides mature follicles, a higher presence of CD45RO positive cells. Thus, the immunoprofile of Kuttner is much more in keeping with an inflammatory-induced degenerative disease than with a preneoplastic lesion.
在本研究中，对慢性硬化性涎腺炎（也称为库特纳瘤）的免疫特征进行了分析。对两名男性患者下颌下腺发生的病例进行了针对不同抗体的免疫组化反应。组织学检查显示，下颌下腺呈现出不同程度的萎缩，腺泡破坏，有炎性细胞浸润以及导管周围纤维化。细胞角蛋白（CKs）反应显示，腺泡和导管残余物对CKs 7、8、19和13呈阳性。CK14染色显示，保留的腺泡和闰管周围的肌上皮细胞以及排泄管的基底细胞呈阳性，但在增生和分支导管中呈阴性。平滑肌肌动蛋白（SMA）由导管周围纤维化中的肌成纤维细胞表达，并且还可见细胞外成分的强烈表达。淋巴细胞标志物显示，除了成熟滤泡外，CD45RO阳性细胞的存在也更多。因此，库特纳瘤的免疫特征更符合炎症诱导的退行性疾病，而不是癌前病变。
