Kisacik Bunyamin, Tufan Abdurrahman, Kalyoncu Umut, Karadag Omer, Akdogan Ali, Ozturk Mehmet Akif, Kiraz Sedat, Ertenli Ihsan, Calguneri Meral
Hacettepe Medical Faculty, Rheumatology Department, Ankara, Turkey.
Joint Bone Spine. 2008 May;75(3):291-4. doi: 10.1016/j.jbspin.2007.06.016. Epub 2008 Apr 9.
The aim of this retrospective study was to investigate the correlation between MPV and the clinical disease activity indices of rheumatoid arthritis and ankylosing spondylitis.
The study consisted of 32 active RA patients (males/females: 7/25, mean age: 49+/-13) and 30 active AS patients (males/females: 15/15, mean age: 36+/-12) along with 26 osteoarthritis (OA) patients (males/females: 4/22, mean age: 52+/-8) and 29 age-matched healthy subjects (males/females: 5/24, mean age: 41+/-7) as control groups for RA and AS, respectively.
MPV was significantly lower in both AS patients and RA patients with active disease as compared to controls (RA vs OA p<0.001, AS vs healthy subjects p<0.001). After treatment MPV values significantly increased in AS and RA (p<0.001 for all). However, MPV values remained somewhat lower in RA patients than OA patients (p=0.019). There was a negative correlation between MPV values and BASDAI scores in AS patients after two months of treatment (r=-0.507; p=0.004).
Our results suggest that assessment of MPV may provide additional information about inflammation in AS and RA.
本回顾性研究旨在调查平均血小板体积（MPV）与类风湿关节炎和强直性脊柱炎临床疾病活动指标之间的相关性。
该研究包括32例活动期类风湿关节炎患者（男/女：7/25，平均年龄：49±13岁）和30例活动期强直性脊柱炎患者（男/女：15/15，平均年龄：36±12岁），以及26例骨关节炎（OA）患者（男/女：4/22，平均年龄：52±8岁）和29例年龄匹配的健康受试者（男/女：5/24，平均年龄：41±7岁），分别作为类风湿关节炎和强直性脊柱炎的对照组。
与对照组相比，活动期强直性脊柱炎患者和类风湿关节炎患者的MPV均显著降低（类风湿关节炎与骨关节炎相比，p<0.001；强直性脊柱炎与健康受试者相比，p<0.001）。治疗后，强直性脊柱炎和类风湿关节炎患者的MPV值均显著升高（均p<0.001）。然而，类风湿关节炎患者的MPV值仍略低于骨关节炎患者（p=0.019）。治疗两个月后，强直性脊柱炎患者的MPV值与巴斯强直性脊柱炎疾病活动指数（BASDAI）评分呈负相关（r=-0.507；p=0.004）。
我们的结果表明，评估MPV可能为强直性脊柱炎和类风湿关节炎的炎症提供额外信息。
