Goulding Ailsa, Taylor Rachael W, Grant Andrea M, Murdoch Linda, Williams Sheila M, Taylor Barry J
Department of Medical and Surgical Sciences, University of Otago, Great King Street, PO Box 913, Dunedin 9054, New Zealand.
Calcif Tissue Int. 2008 Apr;82(4):293-9. doi: 10.1007/s00223-008-9121-x. Epub 2008 Apr 11.
Fat mass was recently shown to be a positive determinant of bone mass and size independently of lean mass in a birth cohort of British 9-year-olds. The present study was undertaken to investigate whether similar relationships are evident in younger, preschool children. Height and weight were measured, and a total-body dual-energy X-ray absorptiometric scan was performed on 194 preschool New Zealand children (81 girls, 113 boys) participating in the Dunedin birth cohort Family, Lifestyle, Activity, Movement, and Eating (FLAME) study close to their fifth birthday. Relationships of total-body fat mass and lean mass to total-body-less-head (TBLH) bone area and TBLH bone mineral content (BMC) were evaluated using linear regression. Girls had higher mean fat mass (3.9 vs. 3.2 kg) and lower lean mass (14.5 vs. 15.2 kg) than boys (P < 0.001), but their heights, weights, and TBLH bone area were similar. Although a given weight of lean tissue was associated with greater increases in TBLH area than a given weight of fat tissue, our results show that fat mass was an independent predictor of TBLH bone area (R (2 )= 0.79, P < 0.001) and TBLH BMC (R (2) = 0.74, P < 0.001) in data adjusted for socioeconomic status, ethnic group, lean mass, and height. We conclude that increased fat mass is associated with outward expansion of the TBLH skeletal envelope (wider bones) independently of height and lean mass in very young children.
最近有研究表明，在一组英国9岁儿童出生队列中，脂肪量是骨量和骨骼大小的正向决定因素，且独立于瘦体重。本研究旨在调查在年龄更小的学龄前儿童中是否也存在类似关系。对参与达尼丁出生队列家庭、生活方式、活动、运动和饮食（FLAME）研究的194名接近5岁的新西兰学龄前儿童（81名女孩，113名男孩）测量了身高和体重，并进行了全身双能X线吸收法扫描。使用线性回归评估全身脂肪量和瘦体重与无头全身（TBLH）骨面积和TBLH骨矿物质含量（BMC）之间的关系。女孩的平均脂肪量（3.9千克对3.2千克）高于男孩，瘦体重（14.5千克对15.2千克）低于男孩（P<0.001），但她们的身高、体重和TBLH骨面积相似。尽管给定重量的瘦组织比给定重量的脂肪组织与TBLH面积的增加更大相关，但我们的结果表明，在根据社会经济地位、种族、瘦体重和身高进行数据调整后，脂肪量是TBLH骨面积（R² = 0.79，P<0.001）和TBLH BMC（R² = 0.74，P<0.001）的独立预测因素。我们得出结论，在非常年幼的儿童中，脂肪量增加与TBLH骨骼包膜向外扩张（骨骼更宽）相关，且独立于身高和瘦体重。
