Lange Ulrich, Roznyatovskaya Nataliya V, Mirsky Vladimir M
Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, D-93040 Regensburg, Germany.
Anal Chim Acta. 2008 Apr 28;614(1):1-26. doi: 10.1016/j.aca.2008.02.068. Epub 2008 Mar 8.
The review covers main applications of conducting polymers in chemical sensors and biosensors. The first part is focused on intrinsic and induced receptor properties of conducting polymers, such as pH sensitivity, sensitivity to inorganic ions and organic molecules as well as sensitivity to gases. Induced receptor properties can be also formed by molecularly imprinted polymerization or by immobilization of biological receptors. Immobilization strategies are reviewed in the second part. The third part is focused on applications of conducting polymers as transducers and includes usual optical (fluorescence, SPR, etc.) and electrical (conductometric, amperometric, potentiometric, etc.) transducing techniques as well as organic chemosensitive semiconductor devices. An assembly of stable sensing structures requires strong binding of conducting polymers to solid supports. These aspects are discussed in the next part. Finally, an application of combinatorial synthesis and high-throughput analysis to the development and optimization of sensing materials is described.
该综述涵盖了导电聚合物在化学传感器和生物传感器中的主要应用。第一部分聚焦于导电聚合物的固有和诱导受体特性，如pH敏感性、对无机离子和有机分子的敏感性以及对气体的敏感性。诱导受体特性也可通过分子印迹聚合或生物受体的固定化形成。第二部分综述了固定化策略。第三部分聚焦于导电聚合物作为换能器的应用，包括常见的光学（荧光、表面等离子体共振等）和电学（电导、安培、电位等）换能技术以及有机化学敏感半导体器件。稳定传感结构的组装需要导电聚合物与固体支持物的强结合。这些方面将在下一部分讨论。最后，描述了组合合成和高通量分析在传感材料开发和优化中的应用。
