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人B淋巴母细胞系中免疫球蛋白重链和轻链V基因融合导致的新型染色体易位。

Novel chromosome translocation caused by fusion of immunoglobulin heavy and light chain V genes in a human B lymphoblastoid cell line.

作者信息

Kennedy M A

机构信息

Department of Pathology, Christchurch School of Medicine, Christchurch Hospital, New Zealand.

出版信息

J Exp Med. 1991 Apr 1;173(4):1033-6. doi: 10.1084/jem.173.4.1033.

DOI:10.1084/jem.173.4.1033
PMID:1840606
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2190807/
Abstract

The chromosome breakpoints of a translocation, t(2;14), from an Epstein-Barr virus-transformed human B lymphoblastoid cell line were isolated and analyzed. This unusual translocation arose as a result of the fusion of two immunoglobulin (Ig) variable (V) genes, one from the heavy chain cluster on chromosome 14, the other from the light chain (k) cluster on chromosome 2. The chromosome breaks occurred within the coding sequence of each gene, and there was no obvious evidence for lymphoid V(D)J recombinase involvement in the translocation. This suggests that breakage and rejoining of the involved V genes occurred by some process other than that which normally rearranges Ig genes.

摘要

从一株爱泼斯坦-巴尔病毒转化的人B淋巴母细胞系中分离并分析了易位t(2;14)的染色体断点。这种不寻常的易位是由于两个免疫球蛋白（Ig）可变（V）基因融合所致，一个来自14号染色体上的重链簇，另一个来自2号染色体上的轻链（κ）簇。染色体断裂发生在每个基因的编码序列内，且没有明显证据表明淋巴样V(D)J重组酶参与了该易位。这表明所涉及的V基因的断裂和重接是通过不同于正常Ig基因重排的某种过程发生的。

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