血清甲胎蛋白阳性患者肝内胆管癌的临床病理特征
Clinicopathologic characteristics of intrahepatic cholangiocarcinoma in patients with positive serum a-fetoprotein.
作者信息
Zhou Yan-Ming, Yang Jia-Mei, Li Bin, Yin Zheng-Feng, Xu Feng, Wang Bin, Liu Peng, Li Zhi-Min
机构信息
Department of Hepato-Biliary-Pancreato-Vascular Surgery, The First Xiamen Hospital, Fujian Medical University, Xiamen, China.
出版信息
World J Gastroenterol. 2008 Apr 14;14(14):2251-4. doi: 10.3748/wjg.14.2251.
Abstract
AIM
To explore clinicopathologic characteristics of intrahepatic cholangiocarcinoma (ICC) in patients with positive serum a-fetoprotein (AFP).
METHODS
One hundred and thirty one patients who underwent surgical dissection for pathologically confirmed ICC were divided into a positive AFP (> 20 ng/mL) group (n = 32) and a negative AFP group (n = 99), whose clinicopathologic features were analyzed and compared.
RESULTS
The positive rate of HBsAg and liver cirrhosis of the positive AFP group was higher than that of the negative AFP group, while the positive rate of CA19-9 (> 37 U/mL) and the lymph node metastasis rate was lower.
CONCLUSION
ICC patients with positive AFP share many clinicopathologic similarities with hepatocellular carcinoma.
摘要
目的
探讨血清甲胎蛋白（AFP）阳性的肝内胆管癌（ICC）患者的临床病理特征。
方法
131例行手术切除且经病理确诊为ICC的患者被分为AFP阳性组（>20 ng/mL，n = 32）和AFP阴性组（n = 99），分析并比较两组的临床病理特征。
结果
AFP阳性组的HBsAg阳性率和肝硬化发生率高于AFP阴性组，而CA19-9（>37 U/mL）阳性率和淋巴结转移率较低。
结论
AFP阳性的ICC患者与肝细胞癌有许多临床病理相似之处。
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