Suzumura Kazuyoshi, Ito Nobuhiro, Nagata Hiroshi, Kotake Katsuhiro, Arikawa Takashi, Ando Keiichi, Nakao Noiku, Kurokawa Tsuyoshi, An Jun, Nonami Toshiaki
Department of Surgery, Division of Gastrointestinal Surgery, Aichi Medical University School of Medicine.
Gan To Kagaku Ryoho. 2008 Apr;35(4):665-8.
A 63-year-old man had undergone a low anterior resection for rectal cancer with multiple liver metastases. Oral UFT (450 mg/day) administration alone was started after the operation. After 6 months post operatively, the patient was diagnosed as anastomosis recurrence because of ileus by abdominal X-ray. Transverse loop colostomy was performed by emergency surgery. After surgery, he suffered from paraplegia for lumbar vertebrae metastases. UFT+LV therapy was started. After chemotherapy a significant reduction of the lymph node and liver metastases and an apparent decrease in CEA and CA19-9 were observed. The patient left the hospital and showed no signs of tumor exacerbation for three months. The patient died of aggravation of primary disease afterwards. The therapy was safe and effective, and has successfully maintained the quality of life (QOL) of this patient.
一名63岁男性因直肠癌伴多发肝转移接受了低位前切除术。术后开始单独口服优福定（450毫克/天）。术后6个月，患者因腹部X线检查显示肠梗阻而被诊断为吻合口复发。急诊手术行横结肠袢式造口术。术后，他因腰椎转移而出现截瘫。开始采用优福定+亚叶酸钙治疗。化疗后，观察到淋巴结和肝转移明显减少，癌胚抗原（CEA）和糖类抗原19-9（CA19-9）明显下降。患者出院，三个月内无肿瘤加重迹象。此后患者死于原发疾病加重。该治疗安全有效，并成功维持了该患者的生活质量（QOL）。
