Wareham Wendy J, Cole Richard P, Royston Sue L, Wright Philip A
Wessex Specialist Laser Centre, Department of Plastic and Reconstructive Surgery, Salisbury District Hospital, Salisbury NHS Foundation Trust, Salisbury, Wilts, SP2 8BJ, UK.
Lasers Med Sci. 2009 Mar;24(2):241-6. doi: 10.1007/s10103-008-0560-4. Epub 2008 Apr 17.
A retrospective study was conducted over a 762-day period to investigate the incidence of adverse effects following pulsed dye laser treatment for port wine stains using the Chromos 585 nm pulsed dye laser (PDL). Treatment energy densities typically ranged from 4.0 J/cm(2) to 7.5 J/cm(2). Treatment was predominantly delivered as a 7 mm-diameter pulse of laser light, although a 5 mm pulse was occasionally used. Nine patients experienced one adverse event each, with scabbing, blistering (prolonged in one case that persisted for more than 2 months), hypopigmentation or hyperpigmentation; one of the nine patients developed both blistering and hypopigmentation. The incidence of adverse effects per treatment was 1.4% (1.7% for adults and 0.6% for children). The lower leg was the most common site for an adverse effect; four out of 22 patients (18%) receiving PDL treatment for lower leg port wine stains (PWSs) suffered an adverse effect (three cases of hyperpigmentation and one of hypopigmentation and blistering). Four patients suffered an adverse effect following an increase in the energy density of the laser treatment. There was no statistically significant correlation between laser performance and the occurrence of adverse effects.
进行了一项为期762天的回顾性研究，以调查使用Chromos 585纳米脉冲染料激光（PDL）治疗葡萄酒色斑后不良反应的发生率。治疗能量密度通常在4.0 J/cm²至7.5 J/cm²之间。治疗主要以直径7毫米的激光脉冲进行，不过偶尔也会使用5毫米的脉冲。9名患者各经历了一次不良事件，包括结痂、水疱形成（其中1例持续超过2个月）、色素减退或色素沉着；9名患者中有1名同时出现了水疱形成和色素减退。每次治疗的不良反应发生率为1.4%（成人1.7%，儿童0.6%）。小腿是不良反应最常见的部位；22名接受小腿葡萄酒色斑（PWS）PDL治疗的患者中有4名（18%）出现了不良反应（3例色素沉着、1例色素减退和水疱形成）。4名患者在激光治疗能量密度增加后出现了不良反应。激光性能与不良反应的发生之间没有统计学上的显著相关性。
