诵读困难儿童与正常阅读者在假词阅读任务期间有效连接性的差异：一项功能磁共振成像研究
Differences in effective connectivity between dyslexic children and normal readers during a pseudoword reading task: an fMRI study.
作者信息
Quaglino V, Bourdin B, Czternasty G, Vrignaud P, Fall S, Meyer M E, Berquin P, Devauchelle B, de Marco G
机构信息
Efficience Cognitive Dans les Conduites Humaines d'Apprentissage et de Travail, Ecchat, EA 2092, Université de Picardie Jules-Verne, Amiens, France.
出版信息
Neurophysiol Clin. 2008 Apr;38(2):73-82. doi: 10.1016/j.neucli.2007.12.007. Epub 2008 Feb 4.
PURPOSE
This fMRI study investigated phonological and lexicosemantic processing in dyslexic and in chronological age- and reading level-matched children in a pseudoword reading task.
MATERIALS AND METHODS
The effective connectivity network was compared between the three groups using a structural model including the supramarginal cortex (BA 40; BA: Brodmann area), fusiform cortex (BA 37) and inferior frontal cortex (BA 44/45) areas of the left hemisphere.
RESULTS
The results revealed differences in connectivity patterns. In dyslexic patients, in contrast with chronological age- and reading level-matched groups, no causal relationship was demonstrated between BA 40 and BA 44/45. However, a significant causal relationship was demonstrated between BA 37 and BA 44/45 both in dyslexic children and in the reading level-matched group.
CONCLUSIONS
These findings were interpreted as evidence for a phonological deficit in developmental dyslexia.
目的
本功能磁共振成像（fMRI）研究在一项假词阅读任务中，对诵读困难儿童以及年龄和阅读水平相匹配的儿童的语音和词汇语义加工进行了调查。
材料与方法
使用一个结构模型比较了三组之间的有效连接网络，该模型包括左半球的缘上皮质（BA 40；BA：布罗德曼区）、梭状皮质（BA 37）和额下回皮质（BA 44/45）区域。
结果
结果揭示了连接模式的差异。与年龄和阅读水平相匹配的组相比，在诵读困难患者中，BA 40和BA 44/45之间未显示出因果关系。然而，在诵读困难儿童和阅读水平相匹配的组中，BA 37和BA 44/45之间均显示出显著的因果关系。
结论
这些发现被解释为发育性诵读困难中语音缺陷的证据。
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