Khan F, Ng L, Gonzalez S, Hale T, Turner-Stokes L
University of Melbourne, Department of Rehabilitation Medicine, Poplar Road, Parkville, Melbourne, Victoria, Australia, 3052.
Cochrane Database Syst Rev. 2008 Apr 16;2008(2):CD004957. doi: 10.1002/14651858.CD004957.pub3.
Joint replacements are common procedures and treatment of choice for those with intractable joint pain and disability arising from arthropathy of the hip or knee. Multidisciplinary rehabilitation is considered integral to the outcome of joint replacement.
To assess the evidence for effectiveness of multidisciplinary rehabilitation on activity and participation in adults following hip or knee joint replacement for chronic arthropathy.
We searched the Cochrane Musculoskeletal Group Trials Register, the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE and CINAHL up to September 2006.
Randomised controlled trials (RCTs) that compared organised multidisciplinary rehabilitation with routine services following hip or knee replacement, and included outcome measures of activity and participation in accordance with the International Classification of Functioning, Health and Disability (ICF).
Four authors independently extracted data and assessed methodological quality of included trials.
Five trials (619 participants) met the inclusion criteria; two addressed inpatient rehabilitation (261 participants) and three (358 participants) home-based settings. There were no trials addressing outpatient centre-based programmes. Pooling of data was not possible due to differences in study design and outcomes used. Methodological assessment showed all trials were of low quality. For inpatient settings early commencement of rehabilitation and clinical pathways led to more rapid attainment of functional milestones (disability) (Functional Independence Measure (FIM) transfer WMD 0.5, 95% CI 0.15, 0.85, number needed to treat to benefit (NNTB) = 6, FIM ambulation WMD 1.55 (95%CI 0.96, 2.14), NNTB = 3), shorter hospital stay, fewer post-operative complications and reduced costs in the first three to four months. Home-based multidisciplinary care improved functional gain (Oxford Hip Score (OHS) WMD at 6 months -7.00 (95%CI -10.36, -3.64), NNT = 2 and quality of life (QoL) and reduced hospital stay in the medium term (six months). No trials addressed longer-term outcomes following hip replacement only.
AUTHORS' CONCLUSIONS: Based on the heterogeneity and the low quality of the included trials that precluded pooled meta-analysis, there is silver level evidence that following hip or knee joint replacement, early multidisciplinary rehabilitation can improve outcomes at the level of activity and participation. The optimal intensity, frequency and effects of rehabilitation over a longer period and associated social costs need further study. Future research should focus on improving methodological and scientific rigour of clinical trials, and use of standardised outcome measures, so that results can be pooled for statistical analysis.
关节置换术是常见的手术,是治疗因髋或膝关节病引起的顽固性关节疼痛和残疾患者的首选治疗方法。多学科康复被认为是关节置换术成功的关键组成部分。
评估多学科康复对慢性关节病髋或膝关节置换术后成年人活动和参与能力影响的有效性证据。
我们检索了截至2006年9月的Cochrane肌肉骨骼组试验注册库、Cochrane对照试验中央注册库、MEDLINE、EMBASE和CINAHL。
随机对照试验(RCT),比较髋或膝关节置换术后有组织的多学科康复与常规服务,并包括符合《国际功能、健康和残疾分类》(ICF)的活动和参与结局指标。
四位作者独立提取数据并评估纳入试验的方法学质量。
五项试验(619名参与者)符合纳入标准;两项涉及住院康复(261名参与者),三项(358名参与者)涉及居家康复。没有试验涉及门诊中心项目。由于研究设计和使用结局的差异,无法进行数据合并。方法学评估显示所有试验质量较低。对于住院康复,早期开始康复和临床路径可使功能里程碑(残疾)更快实现(功能独立性测量(FIM)转移加权均数差(WMD)0.5,95%可信区间(CI)0.15,0.85,受益所需治疗人数(NNTB)=6,FIM行走WMD 1.55(95%CI 0.96,2.14),NNTB = 3),住院时间缩短,术后并发症减少,前3至4个月成本降低。居家多学科护理可改善功能改善(6个月时牛津髋关节评分(OHS)WMD -7.00(95%CI -10.36,-3.64),NNT = 2)和生活质量(QoL),并在中期(6个月)缩短住院时间。没有试验仅涉及髋关节置换术后的长期结局。
基于纳入试验的异质性和低质量,无法进行汇总的Meta分析,有中等证据表明髋或膝关节置换术后,早期多学科康复可改善活动和参与水平的结局。康复在更长时期的最佳强度、频率和效果以及相关社会成本需要进一步研究。未来研究应专注于提高临床试验的方法学和科学严谨性,以及使用标准化结局指标,以便能够合并结果进行统计分析。