Esparza-Coss Emilio, Ramirez Marc S, Bankson James A
Department of Imaging Physics, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Magn Reson Med. 2008 May;59(5):1203-6. doi: 10.1002/mrm.21562.
Despite the excellent image-contrast capability of MRI and the ability to synchronize MRI with the murine cardiac cycle, this technique is underused for assessing mouse models of cardiovascular disease because of its perceived cost and complexity. This perception stems, in part, from complications associated with the placement and adjustment of electrocardiographic leads that may interact with gradient pulses and the relatively long acquisition times required with traditional gating schemes. To improve the efficiency and reduce the cost and complexity of using cardiac MRI in mice, we combined wireless self-gating techniques (with which we derived cardiac synchronization signals from acquired data) with an imaging technique that acquires multislice cardiac cine images from four mice simultaneously. As a result, the wireless self-gated acquisitions minimized animal preparation time and improved image quality. The simultaneous acquisition of cardiac cine data from multiple animals greatly increased throughput and reduced costs associated with instrument access.
尽管磁共振成像（MRI）具有出色的图像对比度能力，且能够与小鼠心动周期同步，但由于其成本和复杂性，该技术在评估心血管疾病小鼠模型方面的应用并不充分。这种看法部分源于与心电图导联放置和调整相关的并发症，这些导联可能会与梯度脉冲相互作用，以及传统门控方案所需的相对较长的采集时间。为了提高效率并降低在小鼠中使用心脏MRI的成本和复杂性，我们将无线自门控技术（通过该技术我们从采集的数据中获取心脏同步信号）与一种成像技术相结合，该成像技术可同时从四只小鼠获取多层心脏电影图像。结果，无线自门控采集最大限度地减少了动物准备时间并提高了图像质量。同时从多只动物采集心脏电影数据大大提高了通量，并降低了与仪器使用相关的成本。
