Pawela Christopher P, Biswal Bharat B, Cho Younghoon R, Kao Dennis S, Li Rupeng, Jones Seth R, Schulte Marie L, Matloub Hani S, Hudetz Anthony G, Hyde James S
Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
Magn Reson Med. 2008 May;59(5):1021-9. doi: 10.1002/mrm.21524.
Regional-specific average time courses of spontaneous fluctuations in blood oxygen level dependent (BOLD) MRI contrast at 9.4T in lightly anesthetized resting rat brain are formed, and correlation coefficients between time course pairs are interpreted as measures of connectivity. A hierarchy of regional pairwise correlation coefficients (RPCCs) is observed, with the highest values found in the thalamus and cortex, both intra- and interhemisphere, and lower values between the cortex and thalamus. Independent sensory networks are distinguished by two methods: data driven, where task activation defines regions of interest (ROI), and hypothesis driven, where regions are defined by the rat histological atlas. Success in these studies is attributed in part to the use of medetomidine hydrochloride (Domitor) for anesthesia. Consistent results in two different rat-brain systems, the sensorimotor and visual, strongly support the hypothesis that resting-state BOLD fluctuations are conserved across mammalian species and can be used to map brain systems.
在轻度麻醉的静息大鼠大脑中，形成了9.4T血氧水平依赖（BOLD）MRI对比自发波动的区域特异性平均时间进程，并且时间进程对之间的相关系数被解释为连接性的度量。观察到区域成对相关系数（RPCC）的层次结构，半球内和半球间的丘脑和皮质中值最高，皮质和丘脑之间的值较低。通过两种方法区分独立的感觉网络：数据驱动，其中任务激活定义感兴趣区域（ROI）；假设驱动，其中区域由大鼠组织学图谱定义。这些研究的成功部分归因于使用盐酸美托咪定（多美康）进行麻醉。在感觉运动和视觉这两种不同的大鼠脑系统中获得的一致结果，有力地支持了以下假设：静息态BOLD波动在哺乳动物物种中是保守的，并且可用于绘制脑系统图谱。
