Speranskaia N V, Ozerova I N, Brener E D
Kardiologiia. 1976 Feb;16(2):77-83.
The activity of adenylcyclase in the tissues and the elimination of 3',5'-AMP with urine were studied in rabbits and rats with experimentally induced atherosclerosis. The relationship between the concentration of steroid hormones and the activity of adenylcyclase in the adrenals was studied after varying periods of atherogenic diets. The activity of adenylcyclase was shown to decrease in the liver and the adrenal glands, as well as the concentration of corticosterone in the adrenals and the urine excretion of 3',5'-AMP, when the animals were kept on the atherogenic diet for long periods of time. No changes in the activity of adenylcyclase were noted in the lipid tissues of the animals with atherosclerosis. The concentration of the steroid hormones in the animals with experimental atherosclerosis was directly dependent on the activity of adenylcyclase in the tissues and the urine excretion of 3',5'-AMP. The administration of Cortisole resulted in a sharp increase of 3',5'-AMP excretion and an activation of adenylcyclase in the liver and lipid tissues of both normal animals, and those kept on an atherogenic diet.
对实验性诱发动脉粥样硬化的家兔和大鼠的组织中腺苷酸环化酶活性以及尿中3',5'-AMP的排泄情况进行了研究。在给予不同时期的致动脉粥样硬化饮食后，研究了类固醇激素浓度与肾上腺中腺苷酸环化酶活性之间的关系。结果表明，当动物长期食用致动脉粥样硬化饮食时，肝脏和肾上腺中腺苷酸环化酶的活性降低，肾上腺中皮质酮的浓度以及尿中3',5'-AMP的排泄量也降低。在患有动脉粥样硬化的动物的脂质组织中，未观察到腺苷酸环化酶活性的变化。实验性动脉粥样硬化动物体内类固醇激素的浓度直接取决于组织中腺苷酸环化酶的活性以及尿中3',5'-AMP的排泄量。给予皮质醇后，正常动物以及食用致动脉粥样硬化饮食的动物的肝脏和脂质组织中3',5'-AMP的排泄量急剧增加，腺苷酸环化酶被激活。
