Mori Yoichiro, Fishman Glenn I, Peskin Charles S
Department of Mathematics, University of British Columbia, Vancouver, BC, Canada.
Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6463-8. doi: 10.1073/pnas.0801089105. Epub 2008 Apr 23.
We study cardiac action potential propagation under severe reduction in gap junction conductance. We use a mathematical model of cellular electrical activity that takes into account both three-dimensional geometry and ionic concentration effects. Certain anatomical and biophysical parameters are varied to see their impact on cardiac action potential conduction velocity. This study uncovers quantitative features of ephaptic propagation that differ from previous studies based on one-dimensional models. We also identify a mode of cardiac action potential propagation in which the ephaptic and gap-junction-mediated mechanisms alternate. Our study demonstrates the usefulness of this modeling approach for electrophysiological systems especially when detailed membrane geometry plays an important role.
我们研究了缝隙连接电导严重降低情况下心脏动作电位的传播。我们使用了一个细胞电活动的数学模型，该模型同时考虑了三维几何结构和离子浓度效应。改变某些解剖学和生物物理参数，以观察它们对心脏动作电位传导速度的影响。这项研究揭示了与以往基于一维模型的研究不同的电紧张传播的定量特征。我们还确定了一种心脏动作电位传播模式，其中电紧张和缝隙连接介导的机制交替出现。我们的研究证明了这种建模方法在电生理系统中的实用性，特别是当详细的膜几何结构起重要作用时。
