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1
Protein lysine methyltransferase G9a acts on non-histone targets.
Nat Chem Biol. 2008 Jun;4(6):344-6. doi: 10.1038/nchembio.88. Epub 2008 Apr 27.
2
Automethylation of G9a and its implication in wider substrate specificity and HP1 binding.
Nucleic Acids Res. 2007;35(21):7313-23. doi: 10.1093/nar/gkm726. Epub 2007 Oct 25.
3
Substrate specificity and kinetic mechanism of mammalian G9a histone H3 methyltransferase.
J Biol Chem. 2004 Dec 17;279(51):53248-58. doi: 10.1074/jbc.M409604200. Epub 2004 Oct 14.
5
Histone H3 lysine 9 methyltransferase G9a is a transcriptional coactivator for nuclear receptors.
J Biol Chem. 2006 Mar 31;281(13):8476-85. doi: 10.1074/jbc.M511093200. Epub 2006 Feb 4.
6
Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP.
J Biol Chem. 2006 Jul 21;281(29):20120-8. doi: 10.1074/jbc.M603087200. Epub 2006 May 15.
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Uncovering Enzyme-Specific Post-Translational Modifications: An Overview of Current Methods.
Proteomes. 2025 Aug 11;13(3):37. doi: 10.3390/proteomes13030037.
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Orchestrating epigenetics: a comprehensive review of the methyltransferase SETD6.
Exp Mol Med. 2025 Mar;57(3):533-544. doi: 10.1038/s12276-025-01423-2. Epub 2025 Mar 18.
3
Decoding the protein methylome: Identification, validation, and functional insights.
Bioorg Med Chem. 2025 Feb 1;118:118056. doi: 10.1016/j.bmc.2024.118056. Epub 2024 Dec 28.
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Emergent properties of the lysine methylome reveal regulatory roles via protein interactions and histone mimicry.
Epigenomics. 2025 Jan;17(1):5-20. doi: 10.1080/17501911.2024.2435244. Epub 2024 Dec 5.
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SETDB1 activity is globally directed by H3K14 acetylation via its Triple Tudor Domain.
Nucleic Acids Res. 2024 Dec 11;52(22):13690-13705. doi: 10.1093/nar/gkae1053.
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Discovery of NSD2 non-histone substrates and design of a super-substrate.
Commun Biol. 2024 Jun 8;7(1):707. doi: 10.1038/s42003-024-06395-z.
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Discovery of the First-in-Class G9a/GLP PROTAC Degrader.
J Med Chem. 2024 Apr 25;67(8):6397-6409. doi: 10.1021/acs.jmedchem.3c02394. Epub 2024 Apr 11.
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Discovery of the First-in-class G9a/GLP PROTAC Degrader.
bioRxiv. 2024 Feb 29:2024.02.26.582210. doi: 10.1101/2024.02.26.582210.

本文引用的文献

2
Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation.
Nature. 2007 Oct 18;449(7164):928-32. doi: 10.1038/nature06160. Epub 2007 Sep 26.
3
Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive.
Nature. 2007 Oct 18;449(7164):933-7. doi: 10.1038/nature06166. Epub 2007 Sep 26.
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5
Chromatin modifications and their function.
Cell. 2007 Feb 23;128(4):693-705. doi: 10.1016/j.cell.2007.02.005.
6
Genome-wide and locus-specific DNA hypomethylation in G9a deficient mouse embryonic stem cells.
Genes Cells. 2007 Jan;12(1):1-11. doi: 10.1111/j.1365-2443.2006.01029.x.
9
Structural and sequence motifs of protein (histone) methylation enzymes.
Annu Rev Biophys Biomol Struct. 2005;34:267-94. doi: 10.1146/annurev.biophys.34.040204.144452.

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