Twigger Simon N, Pruitt Kim D, Fernández-Suárez Xosé M, Karolchik Donna, Worley Kim C, Maglott Donna R, Brown Garth, Weinstock George, Gibbs Richard A, Kent Jim, Birney Ewan, Jacob Howard J
Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA.
Nat Genet. 2008 May;40(5):523-7. doi: 10.1038/ng0508-523.
It has been four years since the original publication of the draft sequence of the rat genome. Five groups are now working together to assemble, annotate and release an updated version of the rat genome. As the prevailing model for physiology, complex disease and pharmacological studies, there is an acute need for the rat's genomic resources to keep pace with the rat's prominence in the laboratory. In this commentary, we describe the current status of the rat genome sequence and the plans for its impending 'upgrade'. We then cover the key online resources providing access to the rat genome, including the new SNP views at Ensembl, the RefSeq and Genes databases at the US National Center for Biotechnology Information, Genome Browser at the University of California Santa Cruz and the disease portals for cardiovascular disease and obesity at the Rat Genome Database.
大鼠基因组序列草图首次发表至今已有四年。目前有五个团队共同努力，对大鼠基因组进行组装、注释并发布更新版本。作为生理学、复杂疾病和药理学研究的主流模型，迫切需要大鼠的基因组资源跟上其在实验室中的重要地位。在这篇评论中，我们描述了大鼠基因组序列的当前状态及其即将进行的“升级”计划。然后，我们介绍了获取大鼠基因组的关键在线资源，包括Ensembl的新单核苷酸多态性（SNP）视图、美国国家生物技术信息中心的RefSeq和基因数据库、加利福尼亚大学圣克鲁兹分校的基因组浏览器以及大鼠基因组数据库中针对心血管疾病和肥胖症的疾病门户。
