Rude R K, Stephen A, Nadler J
Department of Medicine, University of Southern California School of Medicine, Los Angeles.
Magnes Trace Elem. 1991;10(2-4):117-21.
Red blood (RBC) ionized magnesium (Mg2+) was determined by nuclear magnetic resonance (NMR) in order to assess the usefulness of this technique as an index of magnesium depletion. Twenty-four normal subjects underwent a 3-week low-Mg diet. The RBC Mg2+ fell from 209 +/- 9.8 microM before diet to 162 +/- 9.3 microM at the end of the 3 weeks (p < 0.001). In patient populations, 22 hypomagnesemic hospitalized patients had a significantly lower RBC Mg than normal (146 +/- 7.1 microM, p < 0.002), and 37 outpatients with diabetes mellitus had a mean RBC Mg2+ of 172 +/- 7.1 microM which was also significantly lower than normal (p < 0.001). These data suggest that determination of RBC Mg2+ may be used to reflect intracellular Mg status.
为评估核磁共振（NMR）技术作为镁缺乏指标的实用性，对红细胞（RBC）中的离子化镁（Mg2+）进行了测定。24名正常受试者接受了为期3周的低镁饮食。红细胞镁离子浓度从饮食前的209±9.8微摩尔/升降至3周后的162±9.3微摩尔/升（p<0.001）。在患者群体中，22名低镁血症住院患者的红细胞镁离子浓度显著低于正常水平（146±7.1微摩尔/升，p<0.002），37名糖尿病门诊患者的红细胞镁离子平均浓度为172±7.1微摩尔/升，也显著低于正常水平（p<0.001）。这些数据表明，测定红细胞镁离子浓度可用于反映细胞内镁的状态。
