Maggio Marcello, De Vita Francesca, Lauretani Fulvio, Nouvenne Antonio, Meschi Tiziana, Ticinesi Andrea, Dominguez Ligia J, Barbagallo Mario, Dall'aglio Elisabetta, Ceda Gian Paolo
Section of Geriatrics, Department of Clinical and Experimental Medicine, University of Parma, Via Gramsci 14, 43100 Parma, Italy ; Geriatric Rehabilitation Department, University-Hospital of Parma, Via Gramsci 14, 43100 Parma, Italy.
Section of Geriatrics, Department of Clinical and Experimental Medicine, University of Parma, Via Gramsci 14, 43100 Parma, Italy.
Int J Endocrinol. 2014;2014:525249. doi: 10.1155/2014/525249. Epub 2014 Mar 3.
The role of nutritional status as key factor of successful aging is very well recognized. Among the different mechanisms by which nutrients may exert their beneficial effects is the modulation of the hormonal anabolic milieu, which is significantly reduced with aging. Undernutrition and anabolic hormonal deficiency frequently coexist in older individuals determining an increased risk of mobility impairment and other adverse outcomes. Mineral assessment has received attention as an important determinant of physical performance. In particular, there is evidence that magnesium exerts a positive influence on anabolic hormonal status, including Testosterone, in men. In this review we summarize data from observational and intervention studies about the role of magnesium in Testosterone bioactivity and the potential underlying mechanisms of this relationship in male subjects. If larger studies will confirm these pivotal data, the combination of hormonal and mineral replacements might be adopted to prevent or delay the onset of disability in the elderly.
营养状况作为成功衰老的关键因素，其作用已得到广泛认可。营养物质发挥有益作用的不同机制之一是调节激素合成代谢环境，而随着年龄增长，这种环境会显著减少。营养不良和合成代谢激素缺乏在老年人中经常同时存在，这增加了行动能力受损和其他不良后果的风险。矿物质评估作为身体机能的重要决定因素受到了关注。特别是，有证据表明镁对男性的合成代谢激素状态，包括睾酮，有积极影响。在这篇综述中，我们总结了观察性和干预性研究的数据，这些数据涉及镁在睾酮生物活性中的作用以及这种关系在男性受试者中的潜在机制。如果更大规模的研究证实了这些关键数据，那么激素和矿物质替代疗法的联合应用可能会被采用，以预防或延缓老年人残疾的发生。
