在斑马鱼发育过程中，mych基因是神经嵴存活所必需的。
The mych gene is required for neural crest survival during zebrafish development.
作者信息
Hong Sung-Kook, Tsang Michael, Dawid Igor B
机构信息
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America.
出版信息
PLoS One. 2008 Apr 30;3(4):e2029. doi: 10.1371/journal.pone.0002029.
BACKGROUND
Among Myc family genes, c-Myc is known to have a role in neural crest specification in Xenopus and in craniofacial development in the mouse. There is no information on the function of other Myc genes in neural crest development, or about any developmental role of zebrafish Myc genes.
PRINCIPAL FINDINGS
We isolated the zebrafish mych (myc homologue) gene. Knockdown of mych leads to severe defects in craniofacial development and in certain other tissues including the eye. These phenotypes appear to be caused by cell death in the neural crest and in the eye field in the anterior brain.
SIGNIFICANCE
Mych is a novel factor required for neural crest cell survival in zebrafish.
背景
在Myc家族基因中，已知c-Myc在非洲爪蟾的神经嵴特化以及小鼠的颅面发育中发挥作用。关于其他Myc基因在神经嵴发育中的功能，或斑马鱼Myc基因的任何发育作用，尚无相关信息。
主要发现
我们分离出了斑马鱼mych（Myc同源物）基因。敲低mych会导致颅面发育以及包括眼睛在内的某些其他组织出现严重缺陷。这些表型似乎是由神经嵴和前脑眼区的细胞死亡引起的。
意义
Mych是斑马鱼神经嵴细胞存活所需的一个新因子。
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