Hayward Steven, de Groot Bert L
School of Computing Sciences and School of Biological Sciences, University of East Anglia, Norwich, UK.
Methods Mol Biol. 2008;443:89-106. doi: 10.1007/978-1-59745-177-2_5.
Normal mode analysis and essential dynamics analysis are powerful methods used for the analysis of collective motions in biomolecules. Their application has led to an appreciation of the importance of protein dynamics in function and the relationship between structure and dynamical behavior. In this chapter, the methods and their implementation are introduced and recent developments such as elastic networks and advanced sampling techniques are described.
正常模式分析和主成分动力学分析是用于分析生物分子集体运动的强大方法。它们的应用使人们认识到蛋白质动力学在功能中的重要性以及结构与动力学行为之间的关系。在本章中，将介绍这些方法及其实现方式，并描述诸如弹性网络和先进采样技术等最新进展。
