多梳蛋白家族基因：维持干细胞活性的平衡
Polycomb group genes: keeping stem cell activity in balance.
作者信息
Sauvageau Martin, Sauvageau Guy
机构信息
Institute for Research in Immunology and Cancer, Montreal, Quebec, Canada.
出版信息
PLoS Biol. 2008 Apr 29;6(4):e113. doi: 10.1371/journal.pbio.0060113.
Abstract
Overexpression of Polycomb group genes is often associated with cancer development, whereas complete deletion results in loss of stem cell activity. New studies show that partial loss of function of Polycomb group genes enhances the activity of blood stem/progenitor cells.
摘要
多梳蛋白家族基因的过表达通常与癌症发展相关，而完全缺失则会导致干细胞活性丧失。新研究表明，多梳蛋白家族基因功能的部分丧失会增强血液干/祖细胞的活性。
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