Fogle M R, Douglas D R, Jumper C A, Straus D C
Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Can J Microbiol. 2008 May;54(5):423-5. doi: 10.1139/w08-024.
Chaetomium globosum is commonly found in water-damaged buildings and produces the mycotoxins chaetoglobosin A and chaetoglobosin C (Ch-A and Ch-C, respectively). While attempting to purify Ch-A and Ch-C, we observed that these mycotoxins were broken down after heating. The objective of this study was to determine the temperature and the amount of time necessary to break down Ch-A and Ch-C. We demonstrated that the amounts of Ch-A were significantly reduced when exposed to 75 degrees C for 24 h and 100 degrees C for 90, 120, or 150 min. Under the same conditions, the levels of Ch-C were also lower (although not significantly). At 175 degrees C, no Ch-A was detected after 15 min and Ch-C was significantly reduced after 30 min. Our findings will aid other researchers who work with these mycotoxins in the future.
球毛壳菌常见于受水损坏的建筑物中，并产生霉菌毒素球毛壳菌素A和球毛壳菌素C（分别为Ch-A和Ch-C）。在尝试纯化Ch-A和Ch-C时，我们观察到这些霉菌毒素在加热后会分解。本研究的目的是确定分解Ch-A和Ch-C所需的温度和时间。我们证明，当暴露于75摄氏度24小时以及100摄氏度90、120或150分钟时，Ch-A的量显著减少。在相同条件下，Ch-C的水平也较低（尽管不显著）。在175摄氏度时，15分钟后未检测到Ch-A，30分钟后Ch-C显著减少。我们的研究结果将有助于未来其他研究这些霉菌毒素的研究人员。
