Nogueiras Rubén, Wilson Hilary, Rohner-Jeanrenaud Françoise, Tschöp Matthias H
Department of Psychiatry, Obesity Research Centre, University of Cincinnati, Cincinnati, OH 45226, USA.
Regul Pept. 2008 Aug 7;149(1-3):26-31. doi: 10.1016/j.regpep.2007.09.034. Epub 2008 Apr 1.
The white adipose tissue was initially largely known only as an energy storage tissue. It is now well recognized that white adipose tissue is a major endocrine and secretory organ, which releases a wide range of protein signals and factors termed adipokines. The regulation of adipocyte metabolism is an important factor for the understanding of obesity, and some mechanisms are still unknown. Many homeostatic processes, including appetite and food intake, are controlled by neuroendocrine circuits involving the central nervous system. There is substantial evidence demonstrating that the central nervous system also directly regulates adipocyte metabolism. In this review, we discuss the central actions of some peptides with an important role in energy balance regulation on adipocyte metabolism and the physiological relevance of these actions.
白色脂肪组织最初在很大程度上仅被认为是一种能量储存组织。现在人们已经充分认识到，白色脂肪组织是一个主要的内分泌和分泌器官，它会释放出多种被称为脂肪因子的蛋白质信号和因子。脂肪细胞代谢的调节是理解肥胖的一个重要因素，而一些机制仍不为人知。许多稳态过程，包括食欲和食物摄入，都由涉及中枢神经系统的神经内分泌回路控制。有大量证据表明，中枢神经系统也直接调节脂肪细胞代谢。在这篇综述中，我们讨论了一些在能量平衡调节中起重要作用的肽对脂肪细胞代谢的中枢作用以及这些作用的生理相关性。
