Korman Rachel M, Hetzel Natasha, Knowles Toby G, Harvey Andrea M, Tasker Séverine
The Feline Centre, Langford Veterinary Services, School of Veterinary Sciences, University of Bristol, UK.
J Feline Med Surg. 2013 Feb;15(2):81-90. doi: 10.1177/1098612X12461008. Epub 2012 Sep 18.
The study comprised 180 anaemic cats. Descriptive and survival data were obtained. Cats were classified by aetiology of anaemia development and degenerative, anomalous, metabolic, miscellaneous, neoplastic, infectious, inflammatory, immune-mediated, toxic, traumatic or vascular disease (DAMNITV) classification and anaemia severity. Sixty-four (35.6%) cats had mild [packed cell volume (PCV)/haematocrit (HCT) 20-24.9%], 58 (32.2%) moderate (14-19.9%), 23 (12.8%) severe (11-13.9%) and 35 (19.4%) very severe (<10.9%) anaemia. By aetiology of anaemia development, bone marrow (BM) abnormalities were more common (95, 52.8%) than haemorrhage (37, 20.6%) or haemolysis (19, 10.6%). By DAMNITV classification, infectious diseases were more common (39, 21.7%) than neoplasia (36, 20%), metabolic (21, 11.7%), trauma (15, 8.3%), miscellaneous (14, 7.8%), inflammatory (11, 6.1%), immune-mediated (11, 6.1%), anomalous (8, 4.4%), toxic (2, 1.1%) or vascular disease (1, 0.6%). BM abnormalities were significantly associated with more severe anaemia (P = 0.003). Most cats (112, 62.2%) survived to discharge whereas 55 (30.6%) were euthanased and 13 (7.2%) died. Survival to discharge was not associated with anaemia severity but was associated significantly with aetiology of anaemia development (P = 0.046), as cats with haemolysis were more likely to survive to discharge than cats with BM abnormalities. Survival to discharge was also associated significantly with DAMNITV classification (P = 0.010), with cats with neoplasia being less likely, and cats with immune-mediated disease more likely, to survive to discharge. Cox regression analysis found that survival was not associated with anaemia severity, but was associated with DAMNITV classification (P = 0.011) and age (P = 0.082), with cats with immune-mediated disease and younger cats more likely to survive.
该研究纳入了180只贫血猫。获取了描述性和生存数据。根据贫血发生的病因以及退行性、先天性、代谢性、其他、肿瘤性、感染性、炎症性、免疫介导性、中毒性、创伤性或血管性疾病（DAMNITV）分类和贫血严重程度对猫进行分类。64只（35.6%）猫为轻度贫血[红细胞压积（PCV）/血细胞比容（HCT）20 - 24.9%]，58只（32.2%）为中度贫血（14 - 19.9%），23只（12.8%）为重度贫血（11 - 13.9%），35只（19.4%）为极重度贫血（<10.9%）。按贫血发生的病因，骨髓（BM）异常比出血（37只，20.6%）或溶血（19只，10.6%）更常见（95只，52.8%）。按DAMNITV分类，传染病比肿瘤（36只，20%）、代谢性疾病（21只，11.7%）、创伤（15只，8.3%）、其他（14只，7.8%）、炎症性疾病（11只，6.1%）、免疫介导性疾病（11只，6.1%）、先天性疾病（8只，4.4%）、中毒性疾病（2只，1.1%）或血管性疾病（1只，0.6%）更常见（39只，21.7%）。BM异常与更严重的贫血显著相关（P = 0.003）。大多数猫（112只，62.2%）存活至出院，而55只（30.6%）实施了安乐死，13只（7.2%）死亡。存活至出院与贫血严重程度无关，但与贫血发生的病因显著相关（P = 0.046），因为溶血的猫比BM异常的猫更有可能存活至出院。存活至出院也与DAMNITV分类显著相关（P = 0.010），肿瘤猫存活至出院的可能性较小，而免疫介导性疾病猫存活至出院的可能性较大。Cox回归分析发现，生存与贫血严重程度无关，但与DAMNITV分类（P = 0.011）和年龄（P = 0.082）有关，免疫介导性疾病猫和年轻猫更有可能存活。
