B细胞活化因子与外周B细胞耐受性的可塑性
BAFF and the plasticity of peripheral B cell tolerance.
作者信息
Stadanlick Jason E, Cancro Michael P
机构信息
Department of Pathology and Laboratory Medicine, University of Pennsylvania, 36th and Hamilton Walk, Philadelphia, PA 19104-6082, United States.
出版信息
Curr Opin Immunol. 2008 Apr;20(2):158-61. doi: 10.1016/j.coi.2008.03.015. Epub 2008 May 2.
Abstract
BAFF and its receptors play a crucial role in peripheral B cell selection and survival, by dictating the set point for mature primary B cell numbers and adjusting thresholds for specificity-based selection during transitional differentiation. The notion that selective stringency can be varied on the basis of homeostatic demands reveals a previously unappreciated degree of plasticity in B cell tolerance, and suggests a paradigm that unites peripheral negative and positive selection with the maintenance of mature B cell numbers. Moreover, it implies a developmentally regulated coupling of BCR and BAFF receptors at the transitional stages and beyond.
摘要
BAFF及其受体在外周B细胞的选择和存活中起着关键作用，它们决定成熟初级B细胞数量的设定点，并在过渡分化过程中调整基于特异性选择的阈值。选择性严格性可根据稳态需求而变化的这一观点揭示了B细胞耐受性中一种前所未有的可塑性程度，并提出了一种将外周阴性和阳性选择与成熟B细胞数量维持相结合的范例。此外，这意味着在过渡阶段及之后，BCR和BAFF受体在发育上受到调控的耦合。
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