Culp Kennith R, Cacchione Pamela Z
College of Nursing, University of Iowa, Iowa City, IA 52242, USA.
Appl Nurs Res. 2008 May;21(2):66-74. doi: 10.1016/j.apnr.2006.09.002.
Delirium is physiologically plausible in elderly individuals with a poor nutritional status. We explored body composition, serum protein levels, and delirium in a multicenter long-term care study using bioelectrical impedance analysis (BIA). Estimates from the BIA procedure included the body cell mass and fat-free mass (FFM) of nursing home elderly residents (N = 312). Increased delirium was identified in men and women who were leaner and had lower FFM. Clinical surveillance for delirium in frail elderly individuals with low serum albumin levels and polypharmacy is recommended because of their increased likelihood of having drug toxicities for medications with protein-binding properties.
谵妄在营养状况不佳的老年人中在生理上是合理的。我们在一项多中心长期护理研究中，使用生物电阻抗分析（BIA）探索了身体组成、血清蛋白水平和谵妄之间的关系。BIA程序得出的估计值包括养老院老年居民（N = 312）的身体细胞质量和去脂体重（FFM）。在体型较瘦且FFM较低的男性和女性中发现谵妄发生率增加。建议对血清白蛋白水平低且使用多种药物的体弱老年人进行谵妄临床监测，因为他们对具有蛋白质结合特性的药物发生药物毒性的可能性增加。
