Egloff Sylvain, Murphy Shona
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Trends Genet. 2008 Jun;24(6):280-8. doi: 10.1016/j.tig.2008.03.008. Epub 2008 May 3.
The carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II comprises multiple tandem conserved heptapeptide repeats, unique to this eukaryotic RNA polymerase. This unusual structure provides a docking platform for factors involved in various co-transcriptional events. Recruitment of the appropriate factors at different stages of the transcription cycle is achieved through changing patterns of post-translational modification of the CTD repeats, which create a readable 'code'. A new phosphorylation mark both expands the CTD code and provides the first example of a CTD signal read in a gene type-specific manner. How and when is the code written and read? How does it contribute to transcription and coordinate RNA processing?
RNA聚合酶II最大亚基的羧基末端结构域（CTD）包含多个串联的保守七肽重复序列，这是这种真核RNA聚合酶所特有的。这种不同寻常的结构为参与各种共转录事件的因子提供了一个对接平台。在转录周期的不同阶段招募合适的因子是通过改变CTD重复序列的翻译后修饰模式来实现的，这些修饰模式构成了一种可读的“密码”。一种新的磷酸化标记既扩展了CTD密码，又提供了第一个以基因类型特异性方式读取的CTD信号实例。这个密码是如何编写和读取的？它如何促进转录并协调RNA加工？
