Limas C, Limas C J
Department of Laboratory Medicine, University of Minnesota School of Medicine, Minneapolis.
Circ Res. 1991 Jan;68(1):309-13. doi: 10.1161/01.res.68.1.309.
Short-term (5 days) administration of L-thyroxine (0.1 mg/kg i.p. daily) to adult Sprague-Dawley rats induces a modest degree of cardiac hypertrophy (22% increase in heart weight/body weight ratios) and directionally opposite changes in cardiac adrenoceptors (24% increase in beta-adrenoceptors and 20% decline in alpha 1-adrenoceptors). Pretreatment with colchicine did not affect the ability of L-thyroxine to induce cardiac hypertrophy but prevented its effects on both beta- and alpha 1-adrenoceptors. These results suggest a selective involvement of microtubules in the action of thyroid hormones on the expression of cardiac adrenoceptor genes.
对成年斯普拉格-道利大鼠短期（5天）给予左旋甲状腺素（每天腹腔注射0.1毫克/千克）可诱导一定程度的心脏肥大（心脏重量/体重比增加22%），并使心脏肾上腺素能受体发生方向相反的变化（β-肾上腺素能受体增加24%，α1-肾上腺素能受体减少20%）。用秋水仙碱预处理并不影响左旋甲状腺素诱导心脏肥大的能力，但可阻止其对β-和α1-肾上腺素能受体的作用。这些结果表明，微管选择性地参与了甲状腺激素对心脏肾上腺素能受体基因表达的作用。
