Apollonsky Nataly, Edelman Morris, Johnson Alan, Bhuiya Tawfiqul, Karayalcin Gungor
Division of Pediatric Hematology/Oncology and Stem Cell Transplantation, Department of Pediatrics, Schneider Children's Hospital, New Hyde Park, NY, USA.
J Pediatr Hematol Oncol. 2008 May;30(5):369-72. doi: 10.1097/MPH.0b013e31816392b7.
Intracranial involvement of the Hodgkin disease (HD) is a rare entity. Until now, 9 cases of initial presentation of the HD as a brain tumor with appropriate morphologic and histochemical confirmation were reported. Of the 9 patients, 6 had isolated primary intracranial HD and 3 patients after further investigation were found to have extracranial involvement. Seven patients had nodular sclerosing histology, 1 had mixed cellularity, and in 1 case histology was not reported. We describe a patient with systemic nodular sclerosing HD, who initially presented with a brain mass mimicking meningioma and was found to have disseminated lymphadenopathy and bone involvement.
霍奇金淋巴瘤(HD)的颅内受累是一种罕见情况。截至目前,已有9例HD最初表现为脑肿瘤并经适当形态学和组织化学确诊的病例报道。在这9例患者中,6例为孤立性原发性颅内HD,另外3例经进一步检查发现有颅外受累。7例患者为结节硬化型组织学,1例为混合细胞型,1例未报告组织学情况。我们描述了1例患有系统性结节硬化型HD的患者,该患者最初表现为类似脑膜瘤的脑肿块,随后被发现有弥漫性淋巴结病和骨受累。