极小型胚胎样（VSEL）干细胞：从成体器官中纯化、表征及生物学意义
Very small embryonic-like (VSEL) stem cells: purification from adult organs, characterization, and biological significance.
作者信息
Ratajczak Mariusz Z, Zuba-Surma Ewa K, Machalinski Bogdan, Ratajczak Janina, Kucia Magda
机构信息
Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 South Floyd Street, Louisville, KY 40202, USA.
出版信息
Stem Cell Rev. 2008 Summer;4(2):89-99. doi: 10.1007/s12015-008-9018-0. Epub 2008 May 6.
In this review, we discuss current views of the bone marrow (BM) stem cell (SC) compartment and present data showing that BM contains heterogeneous populations of hematopoietic (H)SCs and non-HSCs. These cells are variously described in the literature as: endothelial progenitor cells (EPCs); mesenchymal (M)SCs; multipotent adult progenitor cells (MAPCs); marrow-isolated adult multilineage inducible (MIAMI) cells; and multipotent adult (MA)SCs. In some cases, it is likely that similar or overlapping populations of primitive SCs in the BM detected using various experimental strategies were assigned different names. Recently, we purified rare CXC chemokine receptor 4 expressing (CXCR4(+)) small SCs from the murine BM that express markers characteristic for embryonic (E)SCs, epiblast (EP)SCs, and primordial germ cells (PGCs). We named these primitive cells very small embryonic-like (VSEL) SCs. Our data indicate that VSELs may differentiate into cells from all three germ layers.
在本综述中，我们讨论了目前对骨髓（BM）干细胞（SC）区室的看法，并展示了数据表明骨髓中含有造血（H）干细胞和非造血干细胞的异质群体。这些细胞在文献中有不同的描述，如：内皮祖细胞（EPCs）；间充质（M）干细胞；多能成体祖细胞（MAPCs）；骨髓分离的成年多谱系诱导（MIAMI）细胞；以及多能成体（MA）干细胞。在某些情况下，使用各种实验策略在骨髓中检测到的原始干细胞群体可能相似或重叠，但却被赋予了不同的名称。最近，我们从小鼠骨髓中纯化出了罕见的表达CXC趋化因子受体4（CXCR4(+)）的小干细胞，这些细胞表达胚胎（E）干细胞、上胚层（EP）干细胞和原始生殖细胞（PGCs）的特征性标志物。我们将这些原始细胞命名为非常小的胚胎样（VSEL）干细胞。我们的数据表明，VSELs可能分化为来自所有三个胚层的细胞。
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