同源框基因在哺乳动物外胚层附属器的模式形成、特化和分化中的作用。
Role of homeobox genes in the patterning, specification, and differentiation of ectodermal appendages in mammals.
作者信息
Duverger Olivier, Morasso Maria I
机构信息
Developmental Skin Biology Unit, National Institute of Arthritis Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA.
出版信息
J Cell Physiol. 2008 Aug;216(2):337-46. doi: 10.1002/jcp.21491.
Abstract
Homeobox genes are an evolutionarily conserved class of transcription factors that are key regulators during developmental processes such as regional specification, patterning, and differentiation. In this review, we summarize the expression pattern, loss- and/or gain-of-function mouse models, and naturally occurring mouse and human mutations of known homeobox genes required for the development of ectodermal appendages.
摘要
同源框基因是一类在进化上保守的转录因子，是诸如区域特化、模式形成和分化等发育过程中的关键调节因子。在本综述中，我们总结了外胚层附属器发育所需的已知同源框基因的表达模式、功能丧失和/或功能获得小鼠模型，以及自然发生的小鼠和人类突变。
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