氯喹可增强塞姆利基森林病毒和脑心肌炎病毒在小鼠体内的复制。
Chloroquine enhances replication of Semliki Forest virus and encephalomyocarditis virus in mice.
作者信息
Maheshwari R K, Srikantan V, Bhartiya D
机构信息
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799.
出版信息
J Virol. 1991 Feb;65(2):992-5. doi: 10.1128/JVI.65.2.992-995.1991.
Abstract
Chloroquine (CHL) has been suggested to play an important role in the development of Burkitt's lymphoma by enhancing Epstein-Barr virus expression. Herpes zoster virus incidence is markedly increased following malaria infection in children being treated with CHL. Recently, CHL has also been shown to dramatically increase the transactivation of Tat protein purified from human immunodeficiency virus. These previous studies indirectly suggest that CHL may be involved in the enhancement of virus replication. This study demonstrates for the first time that CHL indeed enhances Semliki Forest virus and encephalomyocarditis virus replication in mice. These results raise the possible connection between the increased spread of AIDS in endemic malaria areas and the wide use of CHL in those areas for the chemotherapy of malaria.
摘要
氯喹（CHL）被认为通过增强爱泼斯坦-巴尔病毒的表达在伯基特淋巴瘤的发展中起重要作用。在用CHL治疗的儿童疟疾感染后，带状疱疹病毒的发病率显著增加。最近，CHL还被证明能显著增加从人类免疫缺陷病毒中纯化的Tat蛋白的反式激活。这些先前的研究间接表明CHL可能参与病毒复制的增强。本研究首次证明CHL确实能增强小鼠中塞姆利基森林病毒和脑心肌炎病毒的复制。这些结果提出了在疟疾流行地区艾滋病传播增加与该地区广泛使用CHL进行疟疾化疗之间可能存在的联系。
相似文献
1
Chloroquine enhances replication of Semliki Forest virus and encephalomyocarditis virus in mice.氯喹可增强塞姆利基森林病毒和脑心肌炎病毒在小鼠体内的复制。
J Virol. 1991 Feb;65(2):992-5. doi: 10.1128/JVI.65.2.992-995.1991.
2
Chloroquine enhances viral replication and murine disease.氯喹可增强病毒复制及小鼠疾病。
Am J Trop Med Hyg. 2000 Jan;62(1):1-3. doi: 10.4269/ajtmh.2000.62.1.
3
4
Acceleration of viral replication and up-regulation of cytokine levels by antimalarials: implications in malaria-endemic areas.抗疟药对病毒复制的加速作用及细胞因子水平的上调：对疟疾流行地区的影响。
Am J Trop Med Hyg. 1999 Aug;61(2):180-6. doi: 10.4269/ajtmh.1999.61.180.
5
[Effects of chloroquine on the replication of a murine retrovirus].[氯喹对一种鼠逆转录病毒复制的影响]
Bull Soc Pathol Exot. 1996;89(3):175-8.
6
Replication of the A7(74) strain of Semliki Forest virus is restricted in neurons.
Virology. 1993 Aug;195(2):627-37. doi: 10.1006/viro.1993.1414.
7
Effects of interferon in malaria infection.
Immunol Lett. 1990 Aug;25(1-3):53-7. doi: 10.1016/0165-2478(90)90091-4.
8
Anti-viral activity of single-stranded homopolynucleotides against encephalomyocarditis virus and Semliki Forest virus in adult mice without interferon induction.单链同聚核苷酸在不诱导干扰素情况下对成年小鼠脑心肌炎病毒和塞姆利基森林病毒的抗病毒活性。
J Gen Virol. 1976 Jan;30(1):21-39. doi: 10.1099/0022-1317-30-1-21.
9
Peritoneal barrier to the spread of Semliki forest virus in mice.小鼠体内腹膜对Semliki森林病毒传播的屏障作用。
Proc Soc Exp Biol Med. 1989 Jan;190(1):70-8. doi: 10.3181/00379727-190-42831.
10
Anti-viral effects of single-stranded polynucleotides against avirulent Semliki Forest virus infection of mice and avirulent infection of rats with encephalomyocarditis virus.单链多核苷酸对小鼠无毒力塞姆利基森林病毒感染及大鼠脑心肌炎病毒无毒力感染的抗病毒作用。
Arch Virol. 1980;64(1):57-66. doi: 10.1007/BF01317391.
引用本文的文献
1
Multiple Factors Involved in Bone Damage Caused by Chikungunya Virus Infection.基孔肯雅热病毒感染导致骨损伤的多种因素。
Int J Mol Sci. 2023 Aug 23;24(17):13087. doi: 10.3390/ijms241713087.
2
Antivirals and the Potential Benefits of Orally Inhaled Drug Administration in COVID-19 Treatment.抗病毒药物和口服药物给药在 COVID-19 治疗中的潜在益处。
J Pharm Sci. 2022 Oct;111(10):2652-2661. doi: 10.1016/j.xphs.2022.06.004. Epub 2022 Jun 9.
3
Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-]pyrimidines as potential anti-chikungunya agents.作为潜在抗基孔肯雅病毒剂的2-亚芳基噻唑并[3,2-]嘧啶的区域选择性汇聚合成。
RSC Adv. 2020 Jan 31;10(9):5191-5195. doi: 10.1039/d0ra00257g. eCollection 2020 Jan 29.
4
G6PD deficiency, redox homeostasis, and viral infections: implications for SARS-CoV-2 (COVID-19).葡萄糖-6-磷酸脱氢酶（G6PD）缺乏、氧化还原平衡与病毒感染：对严重急性呼吸综合征冠状病毒 2（SARS-CoV-2，即 COVID-19）的影响。
Free Radic Res. 2021 Apr;55(4):364-374. doi: 10.1080/10715762.2020.1866757. Epub 2021 Jan 6.
5
Hydroxychloroquine is associated with slower viral clearance in clinical COVID-19 patients with mild to moderate disease.在患有轻至中度疾病的临床新冠肺炎患者中，羟氯喹与病毒清除较慢有关。
Medicine (Baltimore). 2020 Dec 24;99(52):e23720. doi: 10.1097/MD.0000000000023720.
6
Chloroquine commonly induces hormetic dose responses.氯喹通常会引起适应性剂量反应。
Sci Total Environ. 2021 Feb 10;755(Pt 1):142436. doi: 10.1016/j.scitotenv.2020.142436. Epub 2020 Sep 25.
7
Small-Molecule Inhibitors of Chikungunya Virus: Mechanisms of Action and Antiviral Drug Resistance.小分子抑制剂抗基孔肯雅病毒：作用机制和抗病毒药物耐药性。
Antimicrob Agents Chemother. 2020 Nov 17;64(12). doi: 10.1128/AAC.01788-20.
8
Chloroquine and hydroxychloroquine in the treatment of malaria and repurposing in treating COVID-19.氯喹和羟氯喹在疟疾治疗中的应用和在 COVID-19 治疗中的再利用。
Pharmacol Ther. 2020 Dec;216:107672. doi: 10.1016/j.pharmthera.2020.107672. Epub 2020 Sep 8.
9
Immunomodulatory Effects of Hydroxychloroquine and Chloroquine in Viral Infections and Their Potential Application in Retinal Gene Therapy.羟氯喹和氯喹在病毒感染中的免疫调节作用及其在视网膜基因治疗中的潜在应用。
Int J Mol Sci. 2020 Jul 14;21(14):4972. doi: 10.3390/ijms21144972.
10
Therapeutic use of chloroquine and hydroxychloroquine in COVID-19 and other viral infections: A narrative review.氯喹和羟氯喹在 COVID-19 和其他病毒感染中的治疗用途：叙述性综述。
Travel Med Infect Dis. 2020 May-Jun;35:101735. doi: 10.1016/j.tmaid.2020.101735. Epub 2020 May 6.
本文引用的文献
1
Acquired immunodeficiency syndrome in African patients.非洲患者的获得性免疫缺陷综合征。
N Engl J Med. 1984 Feb 23;310(8):492-7. doi: 10.1056/NEJM198402233100804.
2
Interferons with special emphasis on the immune system.特别关注免疫系统的干扰素。
Adv Immunol. 1983;34:97-140. doi: 10.1016/s0065-2776(08)60378-8.
3
Effect of chloroquine and some other antimalarials on the immune mechanism in experimental animals.
J Pharm Pharmacol. 1984 Apr;36(4):268-9. doi: 10.1111/j.2042-7158.1984.tb04366.x.
4
Antibodies to Epstein-Barr virus in Burkitt's lymphoma and control groups.伯基特淋巴瘤和对照组中针对爱泼斯坦-巴尔病毒的抗体
J Natl Cancer Inst. 1969 Nov;43(5):1147-57.
5
Pre-exposure rabies immunization with human diploid cell vaccine: decreased antibody responses in persons immunized in developing countries.
Am J Trop Med Hyg. 1985 May;34(3):633-47. doi: 10.4269/ajtmh.1985.34.633.
6
Herpes zoster in children following malaria.疟疾后儿童带状疱疹
J Trop Med Hyg. 1985 Aug;88(4):261-4.
7
8
Evaluation of serological cross-reactivity between antibodies to Plasmodium and HTLV-III/LAV.疟原虫抗体与人类嗜T淋巴细胞病毒III型/淋巴腺病相关病毒之间血清学交叉反应性的评估。
Lancet. 1986 Aug 2;2(8501):247-9. doi: 10.1016/s0140-6736(86)92071-4.
9
Cellular uptake of the tat protein from human immunodeficiency virus.来自人类免疫缺陷病毒的tat蛋白的细胞摄取。
Cell. 1988 Dec 23;55(6):1189-93. doi: 10.1016/0092-8674(88)90263-2.
10
Recent developments in the understanding of the pharmacokinetics and mechanism of action of chloroquine.氯喹的药代动力学及作用机制研究的最新进展。
Ther Drug Monit. 1989;11(4):369-79.
Zotero 插件