Tauriainen Sisko, Oikarinen Sami, Taimen Kirsi, Laranne Jussi, Sipilä Markku, Lönnrot Maria, Ilonen Jorma, Simell Olli, Knip Mikael, Hyöty Heikki
Dept. of Virology, University of Tampere Medical School, 33014 University of Tampere, Tampere, Finland.
J Infect Dis. 2008 Jul 1;198(1):35-40. doi: 10.1086/588677.
Human parechovirus (HPeV) 1 is a common virus that infects almost everyone during childhood. Because clinical symptoms are poorly documented, we evaluated the symptoms associated with HPeV1 infection in a cohort of children followed prospectively from birth at 3-month intervals.
Symptoms such as fever, cough, those of the common cold, otitis media, and gastroenteritis were determined from hospital records and from questionnaires administered to the parents of 59 children during regular study visits. HPeV1 infections were diagnosed by measuring neutralizing antibodies in follow-up serum samples. Additionally, HPeV RNA was analyzed in middle ear fluid (MEF) and nasopharyngeal aspirate samples from 33 patients with otitis media by reverse-transcription polymerase chain reaction.
Otitis media showed a clear association with HPeV1 infection-it developed in 50% of the 3-month follow-up periods that yielded evidence for HPeV1 infection but in only 14% of the HPeV1-negative periods (odds ratio [OR], 6.14 [95% confidence interval {CI}, 2.75-13.77]). In children with recurring otitis media, MEF samples were positive for HPeV in 15% of episodes. Cough was also associated with HPeV1 infection, but this association was weaker (OR, 3.67 [95% CI, 1.66-8.09]). Other symptoms were not linked to HPeV1 infection.
HPeV1 infections are common in childhood and may cause otitis media and cough.
人细小病毒（HPeV）1是一种常见病毒，几乎每个人在儿童期都会感染。由于临床症状记录不完善，我们对一组从出生开始每3个月进行一次前瞻性随访的儿童中与HPeV1感染相关的症状进行了评估。
通过医院记录以及在定期研究访视期间向59名儿童的父母发放问卷，确定发热、咳嗽、普通感冒症状、中耳炎和肠胃炎等症状。通过检测随访血清样本中的中和抗体来诊断HPeV1感染。此外，采用逆转录聚合酶链反应对33例中耳炎患者的中耳积液（MEF）和鼻咽抽吸物样本进行HPeV RNA分析。
中耳炎与HPeV1感染存在明显关联——在有证据表明发生HPeV1感染的3个月随访期内，50%出现了中耳炎，而在HPeV1阴性期仅14%出现中耳炎（优势比[OR]为6.14[95%置信区间{CI}为2.75 - 13.77]）。在复发性中耳炎患儿中，15%的发作期MEF样本HPeV呈阳性。咳嗽也与HPeV1感染有关，但这种关联较弱（OR为3.67[95%CI为1.66 - 8.09]）。其他症状与HPeV1感染无关。
HPeV1感染在儿童期很常见，可能导致中耳炎和咳嗽。
