Department of Ophthalmology and Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry University, Pondicherry, India.
Eye (Lond). 2009 Apr;23(4):873-6. doi: 10.1038/eye.2008.124. Epub 2008 May 9.
To report the occurrence of uveitis in patients with prior history of dengue fever.
A case series of patients with uveitis, presenting with ocular symptoms 3-5 months after contracting dengue fever during the dengue epidemic without any other attributable cause for uveitis. The dengue fever had subsided without any complication. None of the patients had any ocular complication during the acute dengue infection. They were treated on the lines of uveitis with local steroids, cycloplegic, and ocular hypotensive medications, when required, and oral steroid in case of posterior segment involvement. Patients' follow-up varied from 3-5 months.
Six patients with serological evidence of prior dengue fever had presented with uveitis not attributable to any other disease. Seven eyes of six patients were affected. Anterior uveitis without any evidence of posterior segment involvement was present in six eyes of five patients whereas one patient had severe vitritis also. The most common symptom was progressive decrease in vision and only three out of seven eyes had evidence of ciliary congestion. All patients promptly responded to the treatment and visual acuity returned to 6/9 or better in five eyes, while 6/24 and 6/18 in other two eyes due to the presence of cataract. None of these patients had recurrence during the follow-up period.
Uveitis in dengue infection is rare and ophthalmologists should be aware of these delayed ophthalmic complications. The prognosis of post-dengue uveitis is good.
报告既往登革热病史患者发生葡萄膜炎的情况。
本研究为一系列病例系列，共纳入 6 例患者，这些患者在登革热流行期间出现眼部症状，其在感染登革热后 3-5 个月，且无其他可归因于葡萄膜炎的病因。登革热已消退且无任何并发症。在急性登革热感染期间，这些患者均无任何眼部并发症。根据葡萄膜炎的治疗方案，给予局部类固醇、睫状肌麻痹剂和降眼压药物治疗（必要时），并在涉及后节时口服类固醇。患者的随访时间为 3-5 个月。
6 例患者有既往登革热的血清学证据，他们发生了无法归因于其他疾病的葡萄膜炎。6 例患者的 7 只眼受累。5 例患者的 6 只眼存在无前节段受累的前葡萄膜炎，而 1 例患者还患有严重的玻璃体炎。最常见的症状是视力逐渐下降，只有 7 只眼中的 3 只眼有睫状充血的证据。所有患者均对治疗有迅速反应，5 只眼中的视力恢复到 6/9 或更好，而另外 2 只眼中的视力为 6/24 和 6/18，这是由于存在白内障。在随访期间，这些患者均无复发。
登革热感染后的葡萄膜炎罕见，眼科医生应注意这些迟发性眼部并发症。登革热后葡萄膜炎的预后良好。
