通过主观症状和对雷贝拉唑的反应，有可能将非糜烂性反流病（NERD）患者分为内镜检查正常组和微小变化组——一项针对日本患者的研究报告。

It is possible to classify non-erosive reflux disease (NERD) patients into endoscopically normal groups and minimal change groups by subjective symptoms and responsiveness to rabeprazole -- a report from a study with Japanese patients.

作者信息

Kusano Motoyasu, Shirai Naohito, Yamaguchi Kanako, Hongo Michio, Chiba Tsutomu, Kinoshita Yoshikazu

机构信息

Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, 3-39-15 Showamachi, Maebashi, Gunma, 371-8511, Japan.

出版信息

Dig Dis Sci. 2008 Dec;53(12):3082-94. doi: 10.1007/s10620-008-0290-2. Epub 2008 May 9.

DOI:10.1007/s10620-008-0290-2

PMID:18465242

Abstract

The hypothesis that non-erosive reflux disease (NERD) patients comprise various subgroups is gaining popularity. This study was conducted to investigate the possibility of categorizing NERD patients according to symptom types and response to acid-suppressive drug rabeprazole (RPZ) 10 mg/day. NERD patients were classified as grade N (endoscopically normal), M (minimal change), or erosive GERD, and answered a 51-item, yes-or-no questionnaire pre and post-treatment. Compared to erosive GERD, clear differences existed in pretreatment prevalence of symptoms and responsiveness to RPZ in grades N and M; the results suggested stomachaches (especially at night) were significant symptoms in grade N and dysmotility-like symptoms like bloated stomach were significant in grade M while gastroesophageal reflux symptoms were significant in erosive GERD. Clinical significance of classifying NERD was indicated from different symptoms and responsiveness to PPI.

摘要

非糜烂性反流病（NERD）患者包含不同亚组的假说越来越受到关注。本研究旨在探讨根据症状类型和对抑酸药物雷贝拉唑（RPZ）10毫克/天的反应对NERD患者进行分类的可能性。NERD患者被分为N级（内镜检查正常）、M级（微小变化）或糜烂性胃食管反流病，并在治疗前后回答一份包含51个是非题的问卷。与糜烂性胃食管反流病相比，N级和M级患者在治疗前症状的患病率和对RPZ的反应存在明显差异；结果表明，腹痛（尤其是夜间）是N级的显著症状，而腹胀等动力障碍样症状在M级较为显著，而胃食管反流症状在糜烂性胃食管反流病中较为显著。从不同症状和对质子泵抑制剂的反应来看，NERD分类具有临床意义。