Heinl Peter, Müller Lenka, Körner Carolin, Singer Robert F, Müller Frank A
University of Erlangen-Nuremberg, Department of Materials Science - Institute of Science and Technology of Metals, Martensstrasse 5, 91058 Erlangen, Germany.
Acta Biomater. 2008 Sep;4(5):1536-44. doi: 10.1016/j.actbio.2008.03.013. Epub 2008 Apr 10.
Selective electron beam melting (SEBM) was successfully used to fabricate novel cellular Ti-6Al-4V structures for orthopaedic applications. Micro computer tomography (microCT) analysis demonstrated the capability to fabricate three-dimensional structures with an interconnected porosity and pore sizes suitable for tissue ingrowth and vascularization. Mechanical properties, such as compressive strength and elastic modulus, of the tested structures were similar to those of human bone. Thus, stress-shielding effects after implantation might be avoided due to a reduced stiffness mismatch between implant and bone. A chemical surface modification using HCl and NaOH induced apatite formation during in vitro bioactivity tests in simulated body fluid under dynamic conditions. The modified bioactive surface is expected to enhance the fixation of the implant in the surrounding bone as well as to improve its long-term stability.
选择性电子束熔化(SEBM)已成功用于制造用于骨科应用的新型多孔Ti-6Al-4V结构。微型计算机断层扫描(microCT)分析表明,能够制造出具有相互连通的孔隙率和适合组织长入及血管化的孔径的三维结构。测试结构的力学性能,如抗压强度和弹性模量,与人骨相似。因此,由于植入物与骨之间的刚度失配降低,植入后可能避免应力屏蔽效应。在动态条件下的模拟体液中进行的体外生物活性测试期间,使用HCl和NaOH进行的化学表面改性诱导了磷灰石形成。改性的生物活性表面有望增强植入物在周围骨中的固定,并提高其长期稳定性。