莫氏内阿米巴在坦桑尼亚艾滋病毒感染人群中的高流行率。
High prevalence of Entamoeba moshkovskii in a Tanzanian HIV population.
作者信息
Beck David L, Doğan Nihal, Maro Venance, Sam Noel E, Shao John, Houpt Eric R
机构信息
Division of Infectious Diseases and International Health, University of Virginia Health System, 409 Lane Road, MR4 2144 Charlottesville, VA 22908-1340, USA.
出版信息
Acta Trop. 2008 Jul;107(1):48-9. doi: 10.1016/j.actatropica.2008.03.013. Epub 2008 Apr 7.
Entamoeba moshkovskii and Entamoeba dispar are microscopically indistinguishable from the pathogenic species Entamoeba histolytica. There are limited data on the prevalence of these commensal infections from Africa. We utilized PCR and antigen detection to evaluate the carriage rate of E. moshkovskii, E. dispar, and E. histolytica infection in stool from a cohort of HIV-suspected or confirmed inpatients from Tanzania. E. histolytica was detected by ELISA in 4% (5/118) while E. moshkovskii and E. dispar were detected by PCR in 13% (18/136) and 5% (7/136) of individuals, respectively (P<0.05). Supporting their commensal nature, neither E. moshkovskii nor E. dispar infection was statistically associated with HIV status, CD4 count, or the presence of diarrhea. These data suggest E. moshkovskii is a common infection in HIV-infected individuals in northern Tanzania and supports the concept that the microscopic detection of Entamoeba should be interpreted cautiously.
莫氏内阿米巴和迪斯帕内阿米巴在显微镜下与致病性物种溶组织内阿米巴无法区分。关于非洲这些共生感染的流行情况的数据有限。我们利用聚合酶链反应（PCR）和抗原检测来评估坦桑尼亚一组疑似或确诊的住院艾滋病毒患者粪便中莫氏内阿米巴、迪斯帕内阿米巴和溶组织内阿米巴感染的携带率。通过酶联免疫吸附测定（ELISA）检测到4%（5/118）的个体感染了溶组织内阿米巴，而通过PCR分别检测到13%（18/136）和5%（7/136）的个体感染了莫氏内阿米巴和迪斯帕内阿米巴（P<0.05）。支持它们的共生性质的是，莫氏内阿米巴和迪斯帕内阿米巴感染在统计学上均与艾滋病毒感染状态、CD4细胞计数或腹泻的存在无关。这些数据表明，莫氏内阿米巴在坦桑尼亚北部艾滋病毒感染个体中是一种常见感染，并支持应谨慎解释显微镜下检测到的内阿米巴的这一概念。
Zotero 插件