Unitat de Fisiologia Departament de Bioquímica i Fisiologia Facultat de Biologia Av. Diagonal 645 Barcelona 08028 Spain.
Mediators Inflamm. 1993;2(1):79-83. doi: 10.1155/S0962935193000110.
Hepatic changes during inflammation were studied in rats bearing a carrageenan induced granuloma. In spite of a decrease in the metabolic capacity of microsomes to induce lipid peroxidation during inflammation, the endogenous lipid peroxidation remained unchanged and unrelated with the hepatic activities measured. The continuous increase in hepatic cAMP observed during acute and chronic phases could be related to adenylate cyclase stimulation by mediators, and could be an initial step in the hepatocyte adaptation leading to the increased level of hepatic caeruloplasmin, to the reduction of cytochrome P-450 level and to the modifications of Ca(2+) sequestration by microsomes.
在患有角叉菜胶诱导的肉芽肿的大鼠中研究了炎症期间的肝变化。尽管在炎症期间微粒体诱导脂质过氧化的代谢能力下降,但内源性脂质过氧化仍保持不变,与所测量的肝活性无关。在急性和慢性阶段观察到的肝 cAMP 的持续增加可能与介质刺激的腺苷酸环化酶有关,并且可能是导致肝铜蓝蛋白水平升高、细胞色素 P-450 水平降低以及微粒体对 Ca(2+) 螯合的改变的肝细胞适应的初始步骤。